白茅根多糖改善糖尿病小鼠糖脂代谢作用的研究.pdfVIP

302 2012, Vol.33, No.19 食品科学 ※营养卫生 崔 珏，李 超，尤 健，徐晓栋 (徐州工程学院食品(生物)工程学院，江苏 徐州 221008) 摘 要：目的：研究白茅根多糖对糖尿病小鼠糖脂代谢紊乱的改善作用。方法：首先采用腹腔注射链脲佐菌素 (streptozotocin，STZ)的方法构建小鼠糖尿病模型，以盐酸二甲双胍为对照，观察连续灌胃21d不同剂量白茅根多糖 对糖尿病小鼠体质量、葡萄糖耐受量、糖化血清蛋白(GSP)含量、肝糖原含量和血脂代谢的影响。结果：白茅根多 糖可有效改善糖尿病小鼠的血糖和血脂代谢紊乱情况，可显著降低糖尿病小鼠体内的GSP、甘油三酯(TG)、总胆固 醇(TC)、低密度脂蛋白(LDL-C)，升高糖尿病小鼠的肝糖原和高密度脂蛋白(HDL-C) 水平，效果与盐酸二甲双胍相 当。结论：白茅根多糖具有有效调节糖尿病小鼠糖脂代谢紊乱的活性。 ：白茅根多糖；糖尿病；降血糖；血脂 Effects of Imperata cylindrica Polysaccharides on Glucose and Lipid Metabolism in Diabetic Mice CUI Jue，LI Chao ，YOU Jian ，XU Xiao-dong (College of Food (Biology) Engineering, Xuzhou Institute of Technology, Xuzhou 221008, China) Abstract ：Objective: To study the effects of Imperata cylindrica polysaccharides on blood glucose and lipid in diabetic mice. Method: Diabetes was induced by intraperitoneal injection of streptozotocin in mice. The changes of body mass, glucose tolerance, blood lipid parameters, GSP and liver glycogen of mice were examined. Results: Blood glucose and blood lipid levels of diabetic mice were signifi cantly ameliorated by administration of Imperata cylindrica polysaccharides. Compared with diabetic control mice, Imperata cylindrica polysaccharides significantly decreased GSP, TG, TC, and LDL-C levels of mice, and remarkably increased liver glycogen and HDL-C levels. Comparable results were obtained using metformin hydrochloride. Conclusion: Imperata cylindrica polysaccharides are effective in ameliorating the metabolism of blood glucose and lipids in diabetic mice. Key words Imperata cylindrica ： polysaccharides ；diabetes ；hypoglycemic effect ；blood lipid 中图分类号：S896.6；TS201