临床医学 内科 Iron-Deficiency Anemia(缺铁性贫血).pdf

Iron-Deficiency Iron-Deficiency Anemia Anemia Zhongshan Hospital ,Fudan University Zhongshan Hospital ,Fudan University Zou Shanhua Zou Shanhua Definition Definition Absent iron-store Absent iron-store hemoglobin synthesis ↓ hemoglobin synthesis ↓ A microcytic and hypochromic anemia A microcytic and hypochromic anemia The most common nutritional anemia The most common nutritional anemia Iron metabolism : Iron metabolism : Iron source and absorption Iron source and absorption 1.Heme iron： 1.Heme iron： stomach acid,prolease heme oxygenase hemoglobin stomach acid,prolease heme heme oxygenase hemoglobin heme protoporphyrin protoporphyrin iron iron Its absorption is not influenced by food ingrediant Its absorption is not influenced by food ingrediant Iron source and absorption Iron source and absorption 2.Nonheme iron ： 2.Nonheme iron ： 3 ＋ 2+ Fe3 ＋→stomach acid，VitC →Fe2+ Fe →stomach acid，VitC →Fe 3.Contains:10-15mg/d;10% absorbed 3.Contains:10-15mg/d;10% absorbed 4.Absorption portions ：duodenum and upper part of 4.Absorption portions ：duodenum and upper part of jejunum jejunum 5. Absorption rate 5. Absorption rate Iron transportation Iron transportation 2+ 3+ Fe2+ →Fe3+ →ferritin Fe →Fe →fe