[PPT]-2型糖尿病口服药物治疗及进展北京煤炭总医院内分泌科李.pptVIP

GLP-1和GIP 是两类主要的肠促胰素，由于GLP-1可以降低餐后胰高血糖素的分泌，减少食物的摄入，延缓胃排空，促进β细胞的增殖，因此GLP-1在肠促胰素系统中被广泛讨论 * GLP-1被二肽基肽酶-4（DPP-4）降解失活，半衰期仅1-2分钟。安立泽做为一种DPP-4 抑制剂，能延长内源性活性GLP-1活性 * [486-P] The Long-Acting GLP-1 Derivative, NN2211, Restores Beta Cell Sensitivity to Glucose in Subjects with Type 2 Diabetes ANNETTE M. CHANG, GRETHE JAKOBSEN, JEPPE STURIS, BOB AN, MARLA J. SMITH, CATHIE J. BLOEM, ANDRZEJ GALECKI, JEFFREY B. HALTER. Ann Arbor, MI; Bagsvaerd, Denmark; Princeton, NJ. Saturday, June 14, 2003, 5:00 PM, Poster Presentation: Clinical Therapeutics/New Technology - Pharmacologic Treatment of Diabetes or its