32例三阴性乳腺癌临床特征及预后因素研究 word格式.docxVIP

新疆医科大学硕士学位论文clinicalindicators,takingP0.05asstatisticalsignificantandP0.01as conspicuoussignificantstatistical.Results:Thisstudyinvolved295casesof breastcancerpatients,including32casesofTNBCwhichaccountsfor 10.85%andmostofitspathologicaltypeisinvasiveductalcarcinoma.TNBC andnon-TNBCbothhaveahighincidenceofmiddle-agedandtheincidence rateofold-agegroupislow.TNBConsetsinwomenofallagesbothbefore and aftermenopausal.TNBCpatientsaremorelikelytohavelymphnode metastasis(P0.05),andthelocalrecurrenceanddistantmetastasisratesaresignificantly higher than non-TNBC patients (P 0.05). Furthermore，metastasisinbonesismorelikelytooccurthaninorgan.Butthereisno statisticaldifferenceexistsinthedistributionoftumorsize,clinicalstageof TNBCgroups.Bytheendoffollow-up,7cases(21.88%)of32TNBCpatients diedand27cases(10.27%)of263non-TNBCpatientsdied.Thedisease-free survivalcurves(Figure 3.1) has aconspicuous statistical significant betweenTNBCandnon-TNBC,P0.01,andtheoverallsurvivalcurve (Figure3.2)hasasignificantstatisticalsignificant,P0.05.Conclusion: TNBChasstrongaggressiveandthenumberofmetastasislymphnode,local recurrenceanddistantmetastasisrateofTNBCaresignificantlyhigherthan non-TNBC. Metastasis in bones is more likely to occur than in organ. Itsprognosisispoorandworsewithlateageofonset ，lateclinicalstageandlargenumberofpositivelymphnode.Thetumorsizeandthenumberof metastasislymphnodearetheindependentprognosticfactorsforTNBC patients.Keywords：triple- negative breast cancer(TNBC); clinical characteristics;prognosticfactors中英文缩略词对照表英文缩写英文全名中文译名TNBCriple-negativebreast cancer三阴性乳腺癌ERestrogenreceptor雌激素受体PRprogesteronereceptor孕激素受体HER2humanepidermal growthfactor receptor-2人表皮生长因子受体2FISHfluorescentinsitu hybridization荧光原位杂交CISHChromogenicand Fluorescenceinsitu Hybri-dization色素原位杂交法PFSprogression-free survival无进展生存时间OSoveral1survival总生存时间论文独创性说明本人申明所呈交的学位论文是在我个人在导师的指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人已经发表或撰写过的研究成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确的说明并表示了谢意。学位论文作者签名：签字日期：导师签名：签字日