e光结合口服氨甲环酸治疗黄褐斑临床疗效分析 word格式.docxVIP

中文摘要目的：评价E光结合口服氨甲环酸治疗黄褐斑的疗效及安全性。方法：采取临床随机同期对照试验，选择符合黄褐斑临床诊断及纳入标准的患者共60例，按随机排列表法分成治疗组与对照组，每组30例。对照组采用单纯E光治疗，每4周1次，共6次；治疗组采用E光结合口服氨甲环酸治疗，E光治疗方法同对照组，口服氨甲环酸从首次E光治疗当天开始，至最后1次E光治疗后1个月停止，补水、防晒等护理两组相同。E光治疗前、每次E光治疗结束后1个月时对皮损行面积测量及评分并拍照存档，患者全部治疗结束3个月后复诊，再次进行疗效评估。治疗期间随访患者，了解并记录其不良反应。将治疗前后及随访资料汇总，对两组一般资料、全部治疗结束时的疗效、各组间每次E光治疗前后疗效进行统计学比较。结果：共55例完成本研究，治疗组28例，对照组27例。两组疗效比较：E光结合口服氨甲环酸治疗组显效率75.00%，总有效率92.86%，7例患者基本痊愈；单纯E光治疗组显效率37.04%，总有效率70.37%，3例患者基本痊愈，治疗组显效率及总有效率均高于对照组。治疗组第3次E光治疗前、对照组第4次E光治疗前面积与治疗前比较差异有统计学意义（p0.05），提示E光与口服氨甲环酸结合治疗需坚持2次以上、单一E光治疗需坚持3次以上才可见效。全部治疗结束后3个月回访，治疗组2例复发，对照组4例复发。7例患者E光治疗后出现红斑和明显烧灼感，6例患者口服药物后出现轻微胃肠道症状、月经周期或月经量的变化。结论：E光结合口服氨甲环酸治疗黄褐斑较单纯E光有效率高，二者不良反应轻微。关键词：黄褐斑；E光；氨甲环酸；疗效Clinicalstudy on treatmentofMelasmabyElectricLight Synergycombined with OralTranexamicAcidAbstractObjective:Toevaluatetheefficacyandsafetyprofileofelectriclightsynergycombinedwithoraltranexamicacidinthetreatmentofmelasma.Methods:60patientsofmelasmaaccordwiththestandardofclinicaldiagnosisandsurveywereselectedanddividedintotreatmentgroupandcontrolgrouprandomly.Thecontrolgroupwastreatedwithelectriclightsynergyonceevery4weeksfor6timestotally.Thetreatmentgroupwastreatedbyelectriclightsynergycombinedwithoraltranexamicacid，patientsoral tranexamicacidbeginwith electriclightsynergy,andstoppedonemonthafterthelastelectriclightsynergytreatment.Theareaoffacialpigmentationweremeasured,gradedandpicturedbeforeelectriclightsynergytreatmentandonemonthafterthelastelectriclightsynergytreatment.Thepatientswerefollowedup3monthslater.Thecurativeeffectofthesepatientswereevaluatedandthepicturesweretakenagain.Thepatientswerefollowedupduringthestudytocheckoutthesideeffect.Statisticalanalysiswasperformedtoevaluateclinicalefficacy.Results:Atotalof55patientshavecompletedthestudyinwhich28casescomefromtreatmentgroupand27casesfromcontrolgroup.Theefficiencyoftwogroupswascompared:significanteffectiveratesandeffectiveratesoftreatmentgroupis75.00%and92.86%respectively.Andsignificanteffectiveratesandeffectiveratesofcontrolgroupis37.04%