黏膜医学教学（中山大学）斑纹类疾病-七年制 - 副本.pptVIP

CDLE is a kind of self-immunological disease that frequently involves the skin and/or oral mucosa 0.4％～0.5％，female is double of male，usual between 20～40 years old。 Precancerous condition Persistent erythema, the center of the lesion sunked into discoid shape Mainly involve face skin and oral mucosa，skin lesion with adhesion scales, mucosa lesion with radial arranged tiny striae around the lesion. DLE－definition Autoimmunity disease Involves inheritance、infection、physical factors The relationship between SLE and DLE in contraversial two different disease or two different manifistation od one disease in common: belongs to spectrum of disease,the one end is DLE，limiting in skin and mucosa;another end is SLE with spreaded lupus nephritis DLE－etiology Localized type mucosa damage hollowly discoid lupus, with tiny striae around *vermilion of labium is predilection site skin damage erythema、scales、angiotelectasis(毛细血管扩张)、horn plug(毛囊角质栓)、hyperpigmentation or depigmentation systemic symptoms ：exclude SLE Generalized type DLE－clinical features Epithelial hyperkeratosis or parakeratosis The basal cell layer is significantly liquefied, and the gap between the epithelium and the natural layer can form fissures and vesicles, and the basement membrane is not clear. The intrinsic layer capillary dilation, the blood vessels can see glass thrombus.The blood vessels are surrounded by dense lymphocytes (mainly T cells) and a small number of plasma cells, which are infiltrated by blood vessels. Direct immunofluorescence test, there is a continuous, uneven thickness of green fluorescence band, granule or block in the epithelial basement membrane zone, known as lupus band , it is the immunoglobulin (IgG, IgM) and C3 deposits. There is significance in the diagnosis, treatment and prognosis of the disease. The skin lesions of DLE and SLE are about 90% of the incidence of lupus. DLE－pathology diagnosis Lesion charaters+laboratory examination