口腔预防医学精品教学（中山大学）7.氟与口腔保健.pptxVIP

Fluoride and dental healthDepartment of Preventive DentistryYe Tao Fluoride and human health Systemic use of fluoride Topical application of fluorideFluoride and human health Distribution in nature Rock and earth Plant（tea tree） Water Atmosphere Fluoride and human health Source of human fluoride Drinking water(main source） Food Air Other source Total amount of F Properly obtain F:0.05~0.07mg/kg/dFluoride and human health Metabolism of F Absorption Speed and extent:溶解性相关 Mechanism:扩散 Site:胃肠道、呼吸道、皮肤、 口腔粘膜Fluoride and human health Metabolism of F Distribution 血液、乳汁和软组织 骨和牙： 氟磷灰石或羟基氟磷灰石 釉质表层＞牙本质＞ 釉质深层 唾液和菌斑Fluoride and human health Metabolism of F Excretion Principal route：肾脏 氟清除率与尿PH和流速呈正比 Remaining： 粪便、汗腺、泪液、毛发、指甲Fluoride and human health Mechanism of F against caries Decrease the dissolution of enamel Promote the remineralization F+HA→FHA Effect on bacteria influence?Glycolysis inhibit of intaking GLU inhibit of plaque acidogenesisFluoride and human health Other physiological effect of F? 治疗骨软化和骨质疏松 加速骨折愈合 生殖功能相关 影响神经兴奋传导 促进铁吸收Fluoride and human health Toxicology of fluorid 可能中毒剂量（PTD）：5mg/kg Acute fluorid toxicity 症状：恶心→昏迷 处理原则：催吐、洗胃、支持 Chronic fluorid toxicity 地方性氟中毒 饮水 燃煤 工业性氟中毒 Fluoride and human health Chronic fluorid toxicitySkeletal fluorosis and Dental fluorosis与氟牙症 Fluoride and human health Dental fluorosis 一种特殊的釉质发育不全 Clinical features 恒牙多见，乳牙少见 患牙数取决于高氟区生活史 白斑-黄褐色-实质性缺损 耐磨性差、耐酸 Fluoride and human healthFluoride and human health Dental fluorosis Differential Diagnosis Enamel hypoplasia Tetracycline pigmentation teeth Prevention and treatment 限制氟摄入 脱色、树脂、贴面、冠修复Fluoride and human healthEnamel hypoplasiaTetracycline pigmentation teethSystemic use of Fluoride Water fluoridation Salt fluoridation Milk fluoridation Fluoride tablet and drop Systemic use of Fluoride Water fluoridation Histroy Aim prevent caries/no dental fluorosis Systemic use of Fluoride Systemic use of Fluoride Water fluoridation Principle 适宜水氟浓度 0.7～1mg/L 水氟浓度＜0.5mg/L，加氟 水氟浓度