潮汕人群贲门hpylori感染、cd74表达与上皮增生的相关性研究-病理学与病理生理学专业论文 word格式.docxVIP

紧密。2、运用单向方差分析发现：H pylori 感染阴性和 H pylori 感染阳性贲门粘膜中 CD74 表 达有显著的统计学差异（p0.01）；在 H pylori（+）、H pylori（++）、H pylori（+++）各组 之间，随 H pylori 定植密度加重，CD 74 的表达相应增强，各组间的差异均有统计学意义（p0.05）。3、（1）运用卡方检验分析 H pylori 定植密度与炎症等级之间有显著统计学意义 X2=20.71（p0.01）：炎症等级随着幽门螺杆菌感染程度加重而升高。（2）运用单向方差分析 CD 74蛋白表达水平与炎症等级有统计学意义（p0.05）。4、运用 Spearman 相关分析显示：H.pylori 定植密度、CD74 蛋白表达增强都与 Ki-67 增 殖水平呈正相关（rs 分别为 0.624 和 0.515，p 0.01）结论1、H.pylori 主要定植于贲门粘膜上皮表面和腺体的腺腔内。2、H.Pylori 的定植密度与 CD 74 蛋白的表达水平呈正相关，H.Pylori 与 CD 74 蛋白强表 达的上皮细胞紧密结合，提示 CD 74 作为 H.pylori 的受体，参与并增强 H.pylori 在胃粘膜 上皮定植，是 H.pylori 致病的关键环节之一，并且 CD 74 蛋白可能在 H.Pylori 与贲门上皮 细胞间的信号传导中可能发挥相关的作用。3、H.pylori 感染增加贲门粘膜局部炎症反应，并且 CD74 蛋白表达增加，提示 CD 74 在H.pylori 感染引发的炎症反应中发挥着一定的作用。4、H.pylori 定植密度、CD74 蛋白表达增强均与 Ki-67 增殖水平呈正相关，提示前二者 相互作用在贲门增生等癌前病变中发挥促进作用。【关键词】贲门；癌前病变；H. pylori ；CD74 ；Ki-67AbstractBackground and objectiveH pylori is a microaerophillic gram-negative spiral shaped bacterium ，which colonized in the human gastric mucosa Epidemiologic data suggested its infection rate approximately 50% of the world’s population ，even beyond 80% in developing country. As “Level 1 carcinogenicfactor”, H. pylori infection caused epithelial chronic inflammation, peptic ulcer and gastric mucosal lymphoid tissue (M ALT) lymphoma , and closely related to digestive system tumor, such as gastric adenocarcinoma , even some vascular disease, autoimmune diseases, skin disease, diabetes and other system disease . Although it has been 30 years since Helicobacter pylori was discovered, the nosogenesis, such as route of infection, pathogenesis, particularly corresponding mechanism in tumor occurrence and growth, is unclear. Compared with gastric body and antrum, mucosal cellular structure and pH environment in Cardia is special, which may affect the infection and colonization of helicobacter pylori and so Helicobacter pylori related disease in cardia was rarely reported. Some studies suggest that CD74protein as receptor of H pylori, enhance helicobacter pylori’s adsorption