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老年人常见的疾病-tmatw
2005/12/27 健康與生命科學講座---老年人常見的疾病 成功大學附設醫院家庭醫學部楊宜青醫師 代謝症候群之 定義、生理機轉及流行病學 國立成功大學醫學院 家庭醫學科副教授 楊宜青醫師 「代謝症候群」 是指一群與新陳代謝症狀有關的特徵,容易在同一個人身上出現(危險因素聚集) 這些人將來得到糖尿病及心臟血管疾病的機會也較大。 代謝症候群的緣起 思ㄚ….想ㄚ….起… Reaven Reaven, 1988, Stanford, USA Hyperinsulinemia Impaired Glucose Tolerance Hypertension Triglyceride ↑ HDL↓ Banting lecture Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607 Insulin Resistance: the Metabolic Syndrome X 1999 1st edby Gerald M. Reaven (Editor), Ami Laws (Editor) Kylin E, 1923, Germany The first man recognized clustering of some metabolic abnormalities. The hypertension-hyperglycemia-hyperuricemia syndrome Zentralblatt fuer Innere Medizin 1923;44:105-27 Other: Vague J: Presse Med 1947;30:339-40(upper body obesity) Haller H, Hanefeld M: Lipidstoffwechelstorungen 1975:254-64(Term metabolic syndrome) Hanefeld M, Leohardt W: Dtsch Gesundheitwes 1981;36:545-51 Terms associated with Metabolic Syndrome Metabolic Syndrome (Hanefeld Leonhardt, 1981) (Metabolic) Syndrome X (Reaven, 1988) Deadly Quartet (Kaplan, 1989) Multiple Metabolic Syndrome (Hjermann, Os Nordby, 1992) Insulin Resistance Syndrome (DeFronzo Ferrannini, 1991; Haffner et al.1992 ) Insulin Resistance-dyslipidemia syndrome (Despres, 1993) Chronic cardiovascular risk factor clustering syndrome (Zimmet et al, 1994) Dysmetabolic Syndrome (Groop L,) Cardiovascular Dysmetabolic syndrome (1998) Incongruent Taxonomy Based on: Disease manifestation or Phenotypes Etiologic Conceptualization Purpose Factor Analysis (因素分析) A mathematical technique by which a large number of correlated variables can be reduced to fewer “factors” that represent distinct attributes that account for a large proportion of the variance in the original variables. Factor Extraction?to estimate the numbers of factors Factor Rotation?to determine constituents of each factor in terms of the original variables Exploratory vs Confirmatory FA correlation coefficients Modeling the Str
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