正常高值血压者血压晨峰与冠状动脉病变严重程度-国家心血管病中心.PDFVIP

中国循环杂志 2014 年 4 月 第 29 卷 第 4 期（总第 190 期）Chinese Circulation Journal，April，2014，Vol. 29 No.4（Serial No.190） 265 冠心病研究 正常高值血压者血压晨峰与冠状动脉病变严重程度的相关性 * 梁金排，茶春喜，罗仁 摘要 目的 : 探讨正常高值血压者血压晨峰与冠状动脉病变严重程度的相关性。 方法： 选择正常高值血压可疑冠状动脉性心脏病（冠心病）住院患者 156 例，均完善 24 h 动态血压及冠状动脉造 影检查。根据动态血压结果，将患者分为晨峰组（65 例）和非晨峰组（91 例），比较两组的冠状动脉病变程度。冠状动 脉病变程度用病变支数、分型及 Gensini 总积分表示。 结果： 晨峰组 24 h 平均收缩压、白天平均收缩压及夜间平均收缩压均高于非晨峰组（P 0.05）；晨峰组的收缩压 晨峰高于非晨峰组（P 0.05）；晨峰组冠状动脉病变率、三支病变率及 C 型病变率高于非晨峰组（P 0.01），而单支病 变率和 A 型病变率低于非晨峰组 （P 0.01）；晨峰组 Gensini 总积分显著高于非晨峰组（P 0.01）；晨峰组非杓型血压节 律发生率高于非晨峰组（P 0.05 ）；多元线性回归分析显示，年龄、24 h 平均收缩压及晨峰程度为冠状动脉病变独立 影响因素。 结论： 正常高值血压者血压晨峰与冠状动脉病变程度密切相关。 关键词 冠状动脉病变；血压晨峰； 动态血压；正常高值血压；冠状动脉造影 Relationship Between Morning Blood Pressure Surge and Severity of Coronary Artery Lesions in lndividuals With Normal High Blood Pressure LIANG Jin-pai, CHA Chun-xi, LUO Ren. Shihezi University School of Medicine, Shihezi (832002), Xinjiang, China Corresponding Author: CHA Chun-xi, E-mail: luore163.com Abstract Objective: To investigate the relationship between morning blood pressure surge (MBPS) and severity of coronary artery lesions in patients with normal high blood pressure. Methods: A total of 156 patients of suspicious coronary artery disease (CAD) who received coronary angiography and 24-hour ambulatory blood pressure monitoring (ABPM) were studied. The patients were divided into 2 groups, MBPS group, n = 65 and Non-MBPS group, n =91. The severity of coronary lesions and the classification were measured by the number of vessel involved and Gensini scores, the results were compared between 2 groups. Results: Compared with Non-MBPS group, MBPS group showed increased 24-hour average SBP, day average SBP, night average SBP, P 0.05 and higher morning surge of SBP, P 0.05. MBPS group p