Personalized Nutrition –How to Thrive.pdfVIP

Personalized Nutrition – How to Thrive th UCLA 8 Annual Brain Tumor Conference Carolyn Katzin, MS, CNS Saturday April 19, 2008 © Carolyn Katzin, 2008 Overview What you need to know to improve your outcome and thrive – optimizing your Health Span DNA Integrity and the 3 A’s: Antioxidants Anti-inflammatories Anticarcinogens Symptom management Weight management Supplements – risk or benefit? Your Personal Nutrition Health Check © Carolyn Katzin, 2008 2 Fuel for the brain Glucose is the main fuel for the brain under normal conditions Glucose is crucial for brain function Brain glucose transporter GLUT 3 found in neurons GLUT 3 is not responsive to insulin but depends on blood glucose concentrations Ketones are secondary fuel (derived from fat) rarely used under normal conditions and ketogenic diet should be avoided during chemotherapy The Blood-Brain Barrier (BBB) The brain is protected by a tight wall of endothelial cells and tile-like capillaries called the BBB Brain tissue doesn’t require insulin to take up glucose unlike muscle and most other tissues; glucose is water soluble and is transported across (mediated transport) Some substances are fat soluble and slowly penetrate Many chemicals do not penetrate the barrier at all or do so very slowly (semi permeable) Healthy Brain function depends upon glucose and oxygen Nutrition What You Really Need to Know to Thrive Work with the 3 A’s Antioxidants Anti-inflammatories Anticarcinogens Enhance your natural immunity and resilience Choose foods that balance the 3 A’s Mushrooms, berries and cherries Maintain a healthy weight/waist Moderate your calories to match your