鲍春德—脊柱关节炎的诊断和治疗现状professor Bao精品.pptVIP

有证据提示：SpA越早治疗，疗效越好 Rudwaleit M et al. Ann Rheum Dis. 2008;67:1276-81. 病程越短的AS患者，接受TNF-α拮抗剂治疗疗效越佳 回顾性分析两项以TNF-α拮抗剂为活性药物的RCT中99例AS患者，评估病程、柏林MRI脊柱评分、CRP等对BASDAI50治疗率的影响 阿达木单抗目前在中国获批的适应症为类风湿关节炎和强直性脊柱炎 nr-axSpA治疗小结 nr-axSpA进展较慢，治疗前应对病情进行评估 NSAIDs 及 SASP是nr-axSpA的一线治疗药物 症状重、高水平CRP、MRI提示脊柱、SI关节炎症 指南的推荐内容 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Abstract This first update of the ASAS/EULAR recommendations on the management of ankylosing spondylitis (AS) is based on the original paper, a systematic review of existing recommendations and the literature since 2005 and the discussion and agreement among 21 international experts, 2 patients and 2 physiotherapists in a meeting in February 2010. Each original bullet point was discussed in detail and reworded if necessary. Decisions on new recommendations were made - if necessary after voting. The strength of the recommendations (SOR) was scored on an 11-point numerical rating scale after the meeting by email. These recommendations apply to patients of all ages that fulfill the modified NY criteria for AS, independent of extra-articular manifestations, and they take into account all drug and non-drug interventions related to AS. Four overarching principles were introduced, implying that one bullet has been moved to this section. There are now 11 bullet points including 2 new ones, one related to extra-articular manifestations and one to changes in the disease course. With a mean score of 9.1 (range 8-10) the SOR was generally very good. * NSAIDs相比安慰剂，显著改善患者疼痛 Evaluation of the treatment effect of NSAIDs/TNF blockers according to different domains in ankylosing spondylitis: results of a meta-analysis. Abstract OBJECTIVES: To assess the treatment effect of NSAIDs and TNF blockers in AS according to different domains of interest. METHODS: A systematic literature research was performed in electronic databases up to October 2009. All randomized controlled trials (RCTs) reporting