白芷香豆素黏胶分散型贴剂的制备及体外经皮渗透-中国现代应用药学.PDFVIP

白芷香豆素黏胶分散型贴剂的制备及体外经皮渗透研究  刘晓昱，赖瑛(杭州市中医院临床药学室，杭州 310007) 摘要：目的 制备白芷香豆素黏胶分散型贴剂，考察其离体皮肤渗透性和物理性状，筛选贴剂处方，提高白芷香豆素的 透皮吸收速率。方法 将白芷香豆素分散于尤特奇压敏胶中，采用流涎工艺制备黏胶分散型贴剂。用 Franz 扩散池进行 乳猪离体皮肤渗透实验，用 HPLC 测定欧前胡素的含量，考察了白芷香豆素含量、促渗剂的种类和用量、压敏胶的种类 2 和用量、工艺参数对药物稳态透皮速率和贴剂的物理性状的影响。结果 优选出最佳处方为：药物含量 1.0 mg·cm ， 2 2 2 1 Eudragit E100 9 mg·cm ，油酸 0.6 mg·cm ；固化时间为 40 min ，稳态透皮速率达到 0.82 μg·cm ·h 。结论 制得的黏 胶分散性白芷香豆素贴剂有较高的经皮渗透速率和较好的物理性状，优选出的处方及工艺稳定、可行。 关键词：白芷香豆素；经皮渗透；黏胶分散型；贴剂 中图分类号：R943 文献标志码：B 文章编号：1007-7693(2018)03-0330-05 DOI: 10.13748/ki.issn1007-7693.2018.03.006 引用本文：刘晓昱, 赖瑛. 白芷香豆素黏胶分散性贴剂的制备及体外经皮渗透研究[J]. 中国现代应用药学, 2018, 35(3): 330-334. Preparation of Drug-in Adhesive Patch of Angelica Dahurica Coumarins and Study Its in Vitro Permeability Through Excised Anthony Pig Skin LIU Xiaoyu, LAI Ying(Clinical Pharmacy, Hangzhou Traditional Medical Hosptital, Hangzhou 310007, China) ABSTRACT: OBJECTIVE To prepare the patch of Angelica dahurica coumarins and investigate its transdermal absorption characteristics in vitro. The foumula was chosen to improve the drugs permeation rate. METHODS Angelica dahurica coumarins was dispersed in pressure sensitive adhersive(PSA). A monolithic drug-in-adhesive transdermal patch was developed using sialorrhea technology. The experiment of percutaneous penetration of anthony pig skin in vitro was operated by Franz diffusion cells. HPLC was used to determine drugs content and permeation rate. The influence of some factors on the transdermal flux were inv