Venous System in Acute Brain Injury Mechanisms of Pathophysiological Change and Function（静脉系统在急性脑损伤中的病理生理变化及作用机制）.pdfVIP

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Venous System in Acute Brain Injury Mechanisms of Pathophysiological Change and Function（静脉系统在急性脑损伤中的病理生理变化及作用机制）.pdf

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HHS Public Access Author manuscript A Exp Neurol . Author manuscript; available in PMC 2016 September 14. u t h o r M a n u s c Venous System in Acute Brain Injury: Mechanisms of r i p t Pathophysiological Change and Function #a #b a c c b Sheng Chen , Yujie Chen , Liang Xu , Nathanael Matei , Jiping Tang , Hua Feng , and JohnH Zhangc,* aDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China A u b t Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, h o China r M c a Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California, n u USA s c # r These authors contributed equally to this work. i p t Abstract Cerebral vascular injury is a major component of acute brain injury. Currently, neuroprotective strategies primarily focus on the recanalization of cerebral arteries and capillaries, and the protection of insulted neurons. Hitherto, the role of vein drainage in the pathophysiology of acute A brain injury has been overlooked, due to an under appreciation of the magnitude of the impact of u t veins in circulation. In this review, we summarize the changes in the vein morphology and h o functions that are known, or likely to occur related to acute brain injury, and aim to advance the r M therapeutic management of acute brain injury by