SIBO patients with Parkinson’s disea37.pdfVIP

J Neural Transm DOI 10.1007/s00702-016-1612-8 NEUROLOGY AND PRECLINICAL NEUROLOGICAL STUDIES - ORIGINAL ARTICLE Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease 1 1 1 1 1 Xiao-Lu Niu • Li Liu • Zhi-Xiu Song • Qing Li • Zhi-Hua Wang • 1 1 Jian-Long Zhang • He-Hua Li Received: 14 July 2016 / Accepted: 25 August 2016 Springer-Verlag Wien 2016 Abstract Parkinson’s disease (PD) is associated with Keywords Small intestinal bacterial overgrowth gastrointestinal motility abnormalities that could favor the Parkinson’s disease Gastrointestinal dysfunction Motor occurrence of small intestinal bacterial overgrowth (SIBO). function The aim of the study was to assess the prevalence of SIBO in Chinese patients with PD and the potential impact of SIBO on gastrointestinal symptoms and motor function. Introduction 182 consecutive Chinese patients with PD patients and 200 sex, age, and BMI-matched subjects without PD were Small intestinal bacterial overgrowth (SIBO) is a malab- included. All participants underwent the glucose breath test sorption syndrome associated with increased bacterial to assess SIBO. We examined the associations between density above 105 colony-forming units/mL of small factors and SIBO with logistic regression using SPSS. intestinal aspirate and/or the presence of colonic-type Fifty-five of the 182 PD patients were SIBO positive species (Gasbarrini et al. 2007). Previous studies found that (30.2 %; 95 % CI 23.5–36.9 %) compared with 19 of 200 diseases associated with impaired gastrointestinal (GI) in the control group (9.5 %; 9