Measurement of Organochlorines in Commercial汇总.pdf

Measurement of Organochlorines in Commercial Over-the-Counter Fish Oil Preparations Implications for Dietary and Therapeutic Recommendations for Omega-3 Fatty Acids and a Review of the Literature Stacy Foran Melanson, MD, PhD; Elizabeth Lee Lewandrowski, PhD; James G. Flood, PhD; Kent B. Lewandrowski, MD Context.—The consumption of fish high in omega-3 fatty Objective.—To determine the concentrations of poly- acids is advocated by the American Heart Association to chlorinated biphenyls and other organochlorines in 5 over- decrease the risk of coronary artery disease. However, fish the-counter preparations of fish oil. contain environmental toxins such as mercury, polychlor- Design.—The contents of 5 commercial fish oil brands inated biphenyls, and organochlorine pesticides, which were sent for organochlorine analysis. may negate the beneficial cardiovascular effects of fish Results.—The levels of polychlorinated biphenyls and or- meals. Toxin levels vary depending on both the fish source ganochlorines were all below the detectable limit. and the specific toxin, and neither farm-raised nor wild fish Conclusions.—Fish oil supplements are more healthful are toxin free. Fish oil supplements also prevent the pro- than the consumption of fish high in organochlorines. Fish gression of coronary artery disease and reduce cardiovas- oils provide the benefits of omega-3 fatty acids without the cular mortality. However, only sparse data exist on the lev- risk of toxicity. In addition, fish oil supplements have been el of toxins in fish oil. In a previous study we showed that helpful in a variety of diseases, including bipolar disorder the amount of mercury in 5 over-the-counter brands of fis