通络干预对过劳致血管内皮功能障碍的保护作用研究-中西医结合临床专业论文.docxVIP

河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公共和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权归河北医科任。研究生签名：耙遣斜膏ml，——rT导师河北医科大学研究生论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容之外，文中不包括其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。＼7研究生签名：辫谴斜导师签警：∥留’少J。。f年夕月留日7㈣㈣㈣棚㈣Y1900芗4Jj；|}。目录中文摘要1英文摘要6英文缩写．13研究论文通络干预对过劳致血管内皮功能障碍的保护作用研究引言···································．14第一部分过度疲劳对大鼠主动脉内皮结构和功能的影响及通络干预作用—L￡．—j_．日lJ吾””“”” “”””““”“”一一．．”“”“””” ”一一“一” “一··17材料与方法17结果······················ ····· ················· · ·········2l附I药23附表········ ·· ················· ············ ························30讨论··· ······· ······················· ········· ·········· ·····33／J、结· ······· ··- 36参考文献36第二部分过度疲劳对大鼠血清SOD、MDA及主动脉LOX一1受体表达的影响及通络干预作用前言刚吾”一” “一““” ””“””一一“一” “ 一““一”3939材料与方法39结果·· ···· ··· ········· ··· ····· · 45附图··································································46 附表························································· ·········· ·····47讨论·······························································48小结·························································50参考文献50第三部分过度疲劳对大鼠磷脂酶A2和GPR4受体表达的影响及通络干预作用前言月lJ吾“””一一“”““”“ ”“”““””””””“““““”“”3252材料与方法52结果························ ··························· ······55附图·······································57附表······················································59讨论·········· · ·································· ·····················60／』、结··································································63参考文献63结论······ ·················· ·······································66综述一氧化低密度脂蛋白损伤血管内皮细胞机制研究进展67综述二磷脂代谢与血管病变发生研究73致谢···················································79个人简历80中文摘要通络干预对过劳致血管内皮功能障碍的保护作用研究摘要目的：社会心理因素在血管病变发生中具有重要影响，过度疲劳应激与心脑血管事件的发生发展关系密切。中医脉络学说认为过劳所致络气虚滞是脉络病变由功能性病变向器质性病变发展的早期阶段，为“脉络～血管系统病”始动因素并贯穿