内源性含硫气体分子的心血管调节（英文）-课件.pptVIP

H2S and Cardiovascular Diseases Hypertension Hypoxic pulmonary hypertension Pulmonary blood flow-induced pulmonary hypertension Vascular calcification Hyperhomocysteinemia (HHcy) Endotoxic and septic shock Myocardial injury coronary artery disease Endogenous H2S production was reduced in ISO-induced myocardial injury H2S Myocardial injury 1 Plasma H2S level ↓ 2 H2S production in the heart↓ 3 CSEmRNA expression↑ Biochem Biophys Res Co, 318 (2004) 756–763 H2S protects the structure and the contractility of the myocardium The mechanism is associated with the getting rid of free radicals H2S M