山药多糖对实验性糖尿病小鼠的治疗及预防作用.pdfVIP

深圳中西医结合杂志 201 1 年6 月 第2 1 卷第3 期 ·133 · 文章编号 〔 〔 1007 -0893(20 11) 03 -0133 -03 山药多糖对实验性糖尿病小鼠的治疗及预防作用 1 2 1 1* 赵长英 朱 伟 胡琼丹 陈贵全 （1. 泸州医学院附属中医院，四川泸州 646000；2. 泸州医学院药学院，四川 泸州 646000） 〔摘 要〕 目的：研究山药多糖对实验性糖尿病小鼠的预防及治疗作用。方法：建立实验性糖尿病小鼠模型，观察山药 对四氧嘧啶糖尿病小鼠血糖的影响，观察预防给药对四氧嘧啶引起的小鼠血糖升高的影响。结果：治疗作用研究表明各 剂量组与模型组比较，在降低糖尿病小鼠血糖、控制体重减轻、提高糖耐受量方面有显著性差异，与阳性药物对照组比 较无统计学意义。预防作用研究表明各剂量组与空白对照组比较，在预防血糖升高、控制体重减轻方面有显著性差异。 结论：山药多糖可显著降低四氧嘧啶糖尿病小鼠的血糖，且预防给药能对抗四氧嘧啶引起的小鼠血糖升高。 〔关键词〕 山药多糖；糖尿病小鼠；治疗；预防 〔中图分类号〕 R-332; R587. 1 〔文献标识码〕 A The Prevention and Therapeutic Effect of Yam Polysaccharide on Experimental Diabetic Mice 1 2 1 1 ZHAO Chang-ying , ZHU Wei , H U Qiong-dan , CHEN Gui-quan * （1.Department of nephropathy and endocrinism, Affiliated Hospital of Chinese medicine of Luzhou Medical College, Sichuan Luzhou 646000;2. Pharmacy faculty of Luzhou Medical College, Sichuan Luzhou 646000） 〔Abstract 〕 ObjectiveTo study the prevention and therapeutic effect of Yam polysaccharide on experimental diabetic mice. MethodsExperimental diabetic model mice were prepared to observe the prevention and therapeutic effect of Yam polysaccharide. The blood glucose was measured to observe the effect of Yam polysa- ccharide in diabetic mice induced by alloxan. ResultsComparing with the model group, the dose treatment groups have a significant difference in reducing blood sugar, control weight loss and improve glucose tolerance. The difference between the dose treatment groups and positive control group was not statistically significant. Conclus