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独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研 究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其 他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集 体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切 法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有 权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和 借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文本论文属于保密□ ，在年解密后适用本授权书。不保密□。（请在以上方框内打“√” ）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录全文缩略语 ······························································································ 1中文摘要 ·································································································· 3英文摘要 ·································································································· 4 前 言 ········································································································ 6 材料和方法 ······························································································ 8 结果 ···································································································· 13 讨论 ···································································································· 19 参考文献 ································································································ 23综述一 ···································································································· 26综述二 ···································································································· 32致谢 ········································································································ 41全文缩略语英文缩写英文全称中文全称t-PAtissue type plasminogen activator组织型纤溶酶原激活物PLGplasminogen纤溶酶原PLplasmin纤溶酶MMPsmatrix metalloproteinases基质金属蛋白酶ILInterleukin白细胞介素TNtenascin黏蛋白RHDRel homology domainRel 同源区域NIKNF-κB-inducible kinaseNF-κB诱导激酶IAPinhibitor of apoptosis protein凋亡蛋白抑制物EGFeffects of growth factor生长因子CBcathepsin B组织蛋白酶 BTADtranscription activation domain转录激活区域COXcyclooxygenase环氧合酶TNFtumor necrosis factor肿瘤坏死因子OSCCoral squamous cell ca