卵巢恶性肿瘤组织谷胱甘肽S转移酶的表达及其与化疗耐药的关系.docVIP

卵巢恶性肿瘤组织谷胱甘肽S转移酶的表达及其与化疗耐药的关系 中华妇产科杂志 1998年第2期第33卷 论著 作者：李力　姚德生　陈心秋　陈发龙 黄薇　张洁清　唐步坚 单位：530021 南宁，广西医科大学附属肿瘤医院妇科 关键词：卵巢肿瘤；谷胱甘肽转移酶类；抗药性；预后 　　【摘要】　目的　检测卵巢肿瘤组织中谷胱甘肽S转移酶(GST-π)的表达，并探讨其与化疗耐药的关系。方法　采用免疫组化SP法对53例卵巢恶性肿瘤、20例卵巢良性肿瘤和17例正常卵巢组织进行GST-π检测，并对相关的临床病理因素进行分析。结果　(1)卵巢恶性肿瘤组织中GST-π表达阳性率为60.4%，卵巢良性肿瘤组织中GST-π表达阳性率仅为10.0%，而正常卵巢组织中则无一例GST-π表达阳性；(2)不同病理类型、临床分期和术后残留灶大小的恶性肿瘤组织中GST-π表达阳性率相比较，差异无显著性；(3)恶性肿瘤中，初治和复发的GST-π表达阳性率分别为47.2%和88.2%；(4)GST-π表达阳性的患者对化疗的有效率低于GST-π表达阴性的患者，前者为37.5%(12/32)，而后者为76.2%(16/21)；(5)GST-π表达阳性的患者治疗后1年及3年生存率低于GST-π表达阴性者。结论　卵巢恶性肿瘤组织中GST-π表达与其化疗耐药有关。GST-π表达的检测对临床判断化疗敏感性和预后有一定的参考价值。 　　The Expression of Glutathione S-transferase π in Human Ovarian Cancer as An Indicator of Resistance to Chemotherapy　　Li Li, Yao Desheng, Chen Xinqiu, et al. Affiliate Tumor Hospital of Guangxi Medical University, Nanning 530021 　　【Abstract】　Objective　To study the relationship between the expression of glutathione S-tranferase π(GST-π) in cancer tissue and the chemoresistance in patients with ovarian carcinoma.Methods 　　The expression of GST-π in 53 cases of ovarian cancer, 20 ovarian benign tumors and 17 normal controls was determined by using immunohistochemical SP method and the results were studied in correlation with some clinical and pathological data.Results (1) Positive expression with GST-π was demonstrated in 60.4% of malignant and 10.0% of benign ovarian tumors while the expression was negative in normal controls. (2) No significant difference for the expressions was shown in relation to the histopathology, the clinical staging and the size of residual tumors after cytoreductive surgery. (3) The positive rate of the expression was 47.2% (17/36) for the initially treated patients while those with tumor recurrence had a positive rate of 88.2% (15/17). (4) GST-π positive cases showed less response rate of 37.5% (12/32) to chemotherapy as compared with that of 76.2%(16/21) for GST-π negative cases. (5) The survival period of the patients with GST-π positive expression wa