分子遗传学教材Protein translation for mol med genetics final part2.pptx

Question;PART I: Protein Synthesis Components PART II: Protein Synthesis Process PART III: Protein Synthesis Regulation PART IV: Posttranslational Processing and Targeting PART V: Protein Synthesis in Medicine ; PART IV: Posttranslational Processing and Targeting ;From DNA to protein;8;Mechanism;GroEL forms two stacked 7-membered rings of 60 kD subunits; GroES is a dome on the top ;11;12;4.2.2 Protein disulfite isomerases pattern disulfide bonds;The corrective disulfide is very important for the structure of secreted proteins and membrane proteins.;4.2.3 Peptidyl prolyl isomerization;Cyclosporine A and Cyclophilin ;4.3 Posttranslational Processing and Modifications of Newly Synthesized Polypeptides; ;Methionine aminopeptidase 2;POMC, a polypeptide hormone precursor, is cleaved into different peptide hormones in different tissues.;Posttranslational Modification;Histone Modification;Histone Code Hypothesis ;Phosphorylation;Amplification or over-expression of HER2 in 30% breast cancer Therapy: monoclonal antibody trastuzumab (Herceptin) Pertuzumab, which inhibits dimerization of HER2 and HER3 receptors tamoxifen ;Protein Glycosylation Common in Eukaryotic Proteins;N-Linked Glycans;O-Linked Glycans;The correctly folded proteins need to be transported to special cellular compartments to exert desired biological functions. AAs sequence on the N-terminus that directs proteins to be transported to proper cellular target sites is called signal sequence.; ; ; ;ER membrane;Ribosome dissociates; ; ; ; ;D. Nuclear Export Signal;PART V: Protein Synthesis in Medicine; ;Online Mendelian Inheritance in Man (OMIM) is a database that catalogues all the known diseases with a genetic component;Uniprot();tRNA structure and modifications ;Human disease associated with tRNA modification;Known chemical structure of tRNA modification linked to human disease;Ribosomopathies ;Congenital Asplenia;Diamond-Blackfan anemia(戴-布二氏贫血);Cirrhosis;Shwachman-Bodian-Diamond syndrome(许氏症) ;Treache