Ischemia and Reperfusion Injury-2014 病理生理学双语教材.pptVIP

;Peroxidation damage;; 1. Ischemia and reperfusion injury （Conception and introduction ） ;2. Etiology Factors;PTCA Percutaneous transluminal coronary angioplasty;?Replantation of a severed limb ;2.2 Factors;Ischemia and organ function;Condition of reperfusion;3 PATHOGENESIS;O2;Oxygen free radical O2 , OH ，H2O2 ，1O2 O2 O2 H2O2 OH H2O ;Xanthin +; Others：NO+ O2 ONOO- Cl ?;ATP; 3.1.2 Respiratory burst of neutrophile-neutrophile ;O2; O2 O2 H2O2 OH H2O Production ↑ Mitochondria dysfunction ??cytochrome-oxydase? Elimination ? Ca 2+↑?Mn-SOD? ;Oxidative stress;Lipid peroxidation;④DNA alteration: chromosome aberration, mutation, blockage ;3.2 Calcium overload;exchange;3.2 Calcium overload;Endothelin injury and neutrophils activation;no-reflow;;Myocardial stunning is the reversible reduction of function of heart contraction1 after reperfusion not accounted for by tissue damage or reduced blood flow. The energy metabolism mainly focus on the generation and utilization of ATP in myocardium. In normally the ischemic injury should relieve after reperfusion recover. It is revealed that the high-energy phosphates stored in heart do not increase followed by reperfusion, instead of deplete further. That means the generation of ATP is lower because the mitochondria damaged by oxygen free radicals and calcium overload.;Myocardial stunning;;Ischemia-reperfusion injury in brain;vasopermeability，membrana mucosa;THE END Thank you