甲氨蝶呤的长期安全性研究的荟萃分析.pdfVIP

Downloaded from on March 12, 2012 - Published by Extended report Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research C Salliot,1 D van der Heijde2 c Additional tables, figure and ABSTRACT develop recommendations for the management of references are published online Objective: To perform a systematic literature review of rheumatic diseases. More background information only at / the long-term safety of methotrexate (MTX) monotherapy on this 3E Initiative and the resulting evidence- content/vol68/issue7 in rheumatoid arthritis (RA). based recommendations on the use of MTX are 1 Paris Descartes University, Methods: A search was performed in Medline, Cochrane published in this issue of the journal.3 This paper Medicine Faculty, Rheumatology and EMBASE. Adults with RA who had received MTX describes the literature review to answer the B Department, Cochin Hospital, Paris, France; 2 Rheumatology monotherapy for more than 2 years were studied. question: ‘‘What is the long-term safety of Department, Leiden University Results: 88 published studies were included. Over 12 methotrexate, including cardiovascular diseases, Medical Centre, Leiden, The years of treatment, the termination rate of MTX due to malignancies, infections and liver toxicity?’’. Netherlands toxicity was less than for sulfasalazine, gold, D- Correspondence to: penicillamine and higher than for hydroxychloroquine (level METHOD