医院葡萄球菌感染临床分析.docVIP

医院葡萄球菌感染临床分析 　　【摘要】 目的了解我院葡萄球菌感染的临床分布及其耐药情况,指导临床合理应用抗生素,控制医院感染。方法 药敏试验采用K-B纸片扩散法,同时进行耐苯唑西林葡萄球菌检测,并结合临床资料进行分析。结果 2006年6月至2009年5月共分离出葡萄球菌262株,其中金黄色葡萄球菌87株(33.1%),占第一位;表皮葡萄球菌76株(29.0%)占第二位;其他如中间葡萄球菌、溶血葡萄球菌、腐生葡萄球菌等均占有一定比例。262株葡萄球菌中共检出耐苯唑西林葡萄球菌(MRS)185株占70.7%,苯唑西林敏感葡萄球菌(MSS)77株。MSS对青霉素和红霉素的耐药率高,分别为81.0%～84.4%和57.7%-61.9%。MRS对万古霉素、头孢西丁、替考拉宁、利福平、呋喃妥因等敏感性高,对其余多种抗生素耐药。结论 临床分离菌中的葡萄球菌日益增多,加强葡萄球菌耐药性检测,对于正确合理选用抗菌药和控制葡萄球菌耐药性产生十分重要。 　　【关键词】 葡萄球菌;抗生素;药敏试验 　　 　　Clinical analysis of Staphylococcus infection of hospital 　　 　　GAO Rong-xiang.Luozhuang central Hospital of Linyi,Linyi,276017,China 　　 　　【Abstract】 Objective To investigate the clinical distribution and antimicrobial bacterial resistance of Staphylococcus and to direct the clinic to use antibiotic correctly and decrease nosocomiai infections in our hospital.Methods Disc diffusion test (K-B) was used to study the 　　antimicrobial resistance. Results 262 strains of Staphylococcus were collected from July,2006 to May,2009.87 strains ofStaphylococcus aurous (33.1%) is in the first place, 76 strains ofStaphylococcus epidermidis (29.0%)is in the second place, other(such as S.intermedius, S.haemolyticus, S.saprophyticus, et al) are detected.185 MRS strains were isolated and accounted for 70.7% of 262 isolates of Staphylococcus. Among 77 MSS strains, the resistant rates ofpenicillin and erythromycin were 81.0%～84.4% and 57.7%～61.9% respectively. All MRS strains were sensitive to teicoplanin, vancomycin and most of them were sensitive to nitrofurantoin and rifampin, however most of these strains were resistant to the other antibiotics. Conclusion The number of Staphylococcus among clinical isolates as well as their antibiotic resistance are increasing, further enhancing Staphylococcus resistance and characterization of panresistance mechanism to inform the rational use of antimicrobial agents and containment of Staphylococcus resistance. 　　【Key words】Staphylococcus; Antibiotics;Sensitivity test 　　 　　随着广谱抗菌药物及各种侵袭性诊疗操作的广泛应