小剂量氯沙坦与氢氯噻嗪联用对高血压患者尿酸影响.docVIP

小剂量氯沙坦与氢氯噻嗪联用对高血压患者尿酸影响 　　[摘要] 目的 阐明小剂量氯沙坦与氢氯噻嗪联用（简称两药联用）对高血压患者尿酸的影响。 方法 在男性及更年期后的女性中，选择健康体检者35例及未经治疗且尿酸正常的2级、3级高血压患者46例分别为对照组和治疗组；在更年期前的女性中，选择健康体检者16例及与上述治疗组条件相同的高血压患者19例分别为另一对照组和治疗组。在两药联用前及联用后第2、4及6周末检测各组中所有人的尿酸。然后，将对照组在两药联用后3个时间点的尿酸依次与两药联用前比较，对治疗组在两药联用前后4个时间点的尿酸进行两两比较，同时将治疗组和对照组在上述4个相同时间点的尿酸进行比较。结果 在两对比较组中，对照组在两药联用后3个时间点的尿酸与两药联用前比较，差异均无统计学意义（P ＞ 0.05）；治疗组在两药联用前的尿酸高于对照组，并高于两药联用后3个时间点的尿酸，差异均有统计学意义（P ＜ 0.01或0.05）；治疗组在两药联用后3个时间点的尿酸两两比较及分别与对照组在上述4个相同时间点的尿酸比较，差异均无统计学意义（P ＞ 0.05）。 结论 高血压患者体内有尿酸聚集现象，小剂量两药联用可降低其尿酸，但不会造成低尿酸血症。 　　[关键词] 尿酸；氯沙坦；氢氯噻嗪；高血压 　　[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-4721（2012）03（a）-0029-03 　　 　　Influence of combination of small doses of Losartan with Hydrochlorothiazide on uric acid in patients with Hypertension 　　WANG Huilin XIE Dengrong 　　Department of Cardiovasology, the Second Peoples Hospital Haihua General Hospital in Hunan Province, Haihua 418000, China 　　[Abstract] Objective To clarify influence of combination of small doses of Losartan with Hydrochlorothiazide (combination of the two medicines for short) on uric acid (UA) in patients with hypertension. Methods Among men and post-menopausal women, 35 healthy cases and 46 normal UA and untreated patients with 2 or 3 class hypertension were selected as contrast group and treatment group respectively. At the same time, 16 healthy cases and 19 hypertensive patients with the same conditions of the above treatment group among pre-menopausal women constituted another contrast one and treatment one. All individuals’ UA in each group was tested prior to the combination of the two medicines and on the second weekend, the fourth weekend and the sixth weekend after the use of both. Then, in the contrast group, the UA at the three time points after use of the two medicines was compared with that in before the combination of the two medicines. In addition, the treatment group’s UA was pairwise compared at the four points in time before and after using concurrently the two medicines. At the same ti