醋酸地塞米松眼用纳米脂质载体原位凝胶的制备及药效学考察.docVIP

醋酸地塞米松眼用纳米脂质载体原位凝胶的制备及药效学考察 　　【摘要】目的：制备一种眼用醋酸地塞米松纳米脂质载体温敏型原位凝胶，并对其进行药效学考察。方法：采用薄膜-超声法制备醋酸地塞米松纳米脂质载体，并进一步将其制成眼用温敏凝胶，以辣椒酊制造的家兔眼部炎症模型对其进行药效学评价。结果：醋酸地塞米松纳米脂质载体原位凝胶的抗炎效果与等计量的药物PBS滴眼剂相比具有显著性差异（P 0.05）。结论：醋酸地塞米松纳米脂质载体温敏型原位凝胶比普通的滴眼剂具有更好的药效。 　　【关键词】醋酸地塞米松；纳米脂质载体；温敏凝胶；药效 　　 　　The preparation and pharmacodynamic investigation of Dexamethasone Acetate-loaded nanostructured lipid carriers in thermo-sensitive gel 　　 　　【Abstract】OBJECTIVE To prepare a formulation of dexamethasone acetate-loaded nanostructured lipid carriers in thermo-sensitive gel (DXM-NLC-GEL) and investigate the pha