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血清CC-16在非吸烟COPD和吸烟COPD患者中的表达 姜红妮1 彭绍华1, 2 张静1 (1 复旦大学附属中山医院呼吸科，上海 200032；2 福建医科大学邵武教学医院，福建莆田学院附属医院，邵武市立医院呼吸科，福建 350108) 通讯作者：张静，复旦大学附属中山医院呼吸科，上海市枫林路180号，200032，zhang.jing@ 摘要 目的 观察慢性阻塞性肺病(chronic obstructive pulmonary disease, COPD)患者中吸烟人群和不吸烟人群血清Clara细胞蛋白(Clara cell protein, CC-16)的表达情况。 方法 入选符合COPD诊断的稳定期患者，记录入选者的基本情况、临床症状及肺功能等信息，并留取血清，通过ELISA方法检测CC-16水平。按照是否有吸烟史将患者分为吸烟COPD和非吸烟COPD进行比较，同时以吸烟和非吸烟的健康体检者做对照。 结果 共入选COPD患者34人，吸烟组 17例，非吸烟组 17例，健康人吸烟组15例，健康人非吸烟对照组19例。吸烟COPD组男性比例更高，和非吸烟COPD组相比有显著性差异。吸烟和非吸烟COPD患者相比年龄、肺功能无显著性差异。COPD患者和健康对照组相比血清CC-16水平显著降低(p0.001)。吸烟和非吸烟COPD之间CC-16血清水平相仿；吸烟健康者和非吸烟健康者相比，血清CC-16呈现下降趋势，但无显著性差异。 结论 血清CC-16在COPD患者中表达水平低于健康体检者，可能成为COPD诊断的生物学标志物之一。吸烟者和非吸烟者相比，血清CC-16有下降趋势，有待大样本研究进一步确证。 关键词：慢性阻塞性肺病；Clara细胞蛋白；吸烟 中图分类号：R563 文献标识码：A 基金资助：上海市卫生和计划生育委员会中医药科研基金 (编号：2014LP004A);上海市科委西医引导类项目(编号：14411965900)。 The serum levels of CC-16 in non-smoking and smoking subjects with COPD Hong-ni Jiang1 Shao-hua Peng1.2 Jing Zhang1* 1 Department of respiration of Zhongshan Hospital Affiliated to Fudan University 2 Department of respiration of Shaowu Municiple Hospital, Fujian Medical University teaching hospital in Shaowu, Fujian Affiliated Hospital of Putian College * Corresponding author: Fenglin Road 180, Shanghai, 200032，zhang.jing@ Abstract Objective To observe the serum levels of Clara cell protein (CC-16) in non-smoking and smoking subjects with chronic obstructive pulmonary disease (COPD). Methods We measured serum CC-16 levels by ELISA from stable COPD patients with or without smoking history, and non-COPD healthy controls with or without smoking history. The basic information, clinical symptoms and lung functions of patients were also collected and analysed. Results There were 17 smoking COPD, 17 non-smoking COPD, 15 smoking non-COPD, 19 non-smoking non-COPD subjects were enrolled. Compared with non-smoking COPD group, there are significantly more males in smoking COPD group, but no differences in age and lung funct