不明原因非典型肺炎局部暴发流行例.docxVIP

不明原因非典型肺炎局部暴发流行26例作者：刘文成,王宗烨,郑成中,苗宁,敬华,李洁,杨戈,姜玉峰,顾颖【关键词】非典型肺炎；传染；流行病学Localepidemicofatypicalpneumoniawithunknowncause:Aclinicalanalysisof26cases【Abstract】AIM:ToinvestigatetheepidemiologicalcharacteristicsandΨclinicalmanifestat茔ionsofatypicalpneu鳐moniawithunknownca员use.METHODS:Clinicaldatawereretrospe旯ctivelyanalyzedin2壮6casesofatypicalpn溪eumoniawithunknown玲cause.RESULTS:Agroupof26patientswereⅳadmittedinthehospiΙtal.Thepatientswor阱kedatthesameinstit嘹utionandresidedint毋hesamebuilding.The⒀mainsymptomwasfeve尥r,withlessornoinfe妒ctiontoxicmanifest殃ationsandrespiratorysymptoms.AlltheX舨rayexaminationssho缟wedmultipleorsolit彰arydotmassiveshado笥wswithhighorincons瀣istentdensity,andt粮heedgeoftheshadows凵wasnotclear.Labora瞬toryassaysdemonstratedthatthenumbero蚍fleukocyteswasdecr告easedornormal,andm樵onocyteswereincrea铋sed.Alltheantibodi品estoknownpathogeni岍eswerenegative.The┣patientswereisolat疳edduringthetreatme淹nt,inwhich16patien酒tsweretreatedwitha汝ntibioticsandantiv好irus,8patientswith艹antivirusonly.Theb邮odytemperaturebeca么menormalinallthepa隽tientsafter5daytre南atment,withoutresp棹iratoryfailureandd混eath.CONCLUSION:Thebasicfeaturesofth鑫epatientsareinacco筹rdwiththoseofatypi铥calpneumoniawithhi侄ghinfectiosity.Res锔piratoryspreadisth鼙emainrouteoftransm论ission.Thediseaseo禺ccursinanaggregatedpopulationwithani穸ncubationperiodofd涎andwithslightsymptクomsandatendencyofs徐pontaneouscure.Pul艚monaryshadowsappea谦rquicklyafteronsetΗofthedisease.【Keれywords】atypicalpne媲umonia;infectiosit逋y;epidermiology【午摘要】目的：探讨不明原因非典型肺炎患者的流行病学特征和临床表现.方法：对猿26例集中发病的不明原因非典型肺炎患嗥者的临床资料进行回顾性研究分析.结果：观察对象中男性18例，女性8例，平险均年龄岁，均为同一单位，同一大楼集体薄居住.主要症状为发热、感染中毒症状，傧呼吸道症状轻或缺如.肺部X线片均表现为多发或单发的点片状密度增高影，密度诨不均，边缘不清.外周血白细胞总数正常垧或降低；单核细胞百分比升高；引起非典型肺炎的常见已知的病原体抗体检测均阴猪性，全部住院隔离治疗；应用甲磺酸培氟沙星/环丙沙星+利巴韦林治疗16例，愤单纯抗病毒治疗8例.26例入院5d体螂温恢复正常.无呼吸衰竭及死亡病例.结措论：本病基本特征符合非典型肺炎特点且哧具有较强传染性，呼吸道为主要传播途径κ；发病呈人群聚集性，发病后迅速出现肺牯部片影；潜伏期~6d.症状轻微，有自芡愈倾向.【关键词】非典型肺炎；传〗染；流行病学【中图号】0引言由于非典型肺炎、禽流感这些呼吸道传酯染病的出现，给人类健康带来极大威胁，吭人们对不明原因非典型肺炎更加重视.某虿单位聚集性发生一批临床表现相同的非典型肺炎小范围暴发流行.8d内共发病2