菊粉和金玉兰对2型糖尿病患者血糖控制和血脂的影响-.docVIP

 菊粉和金玉兰对2型糖尿病患者血糖控制和血脂的影响 刘鹏举 马方 李明 卢洁 陈晓强 【摘要】 目的 研究菊粉和金玉兰对2型糖尿病患者血糖控制和血脂代谢的效果。方法 75例2型糖尿病患者按照性别和体重指数匹配的方法分为菊粉组(n=25)、金玉兰组(n=25)和对照组(n=25)，三组患者均给予普通糖尿病膳食，在此基础上菊粉组每天给予菊粉15克，金玉兰组每天给予金玉兰120克。分别于基线期、4周和8周时观察三组患者的空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)、血脂、转氨酶和肌酐等指标的变化并进行比较。结果 菊粉组、金玉兰组及对照组完成研究的人数分别是23人、22人和23人。4周时，菊粉组的FBG、HbA1c、HOMA-IR、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)同对照组相比有降低的趋势；8周时，菊粉组患者的FBG、HbA1c、HOMA-IR、TC、LDL同对照组相比显著降低(P0.05)，其余观察指标无显著变化(P0.05)。4周和8周时，金玉兰组的各项指标变化同对照组相比无显著变化(P0.05)。结论 菊粉有益于2型糖尿病患者的血糖控制和血脂代谢，并且对肝、肾功能无影响。 【关键词】菊粉；金玉兰；2型糖尿病；糖化血红蛋白；血脂 The effects of inulin and Chicory on glucose control and lipid profiles in patients with type 2 diabetes 【Abstract】 Objective To investigate the effects of inulin and Chicory on glucose control and lipid profiles in patients with type 2 diabetes. Methods Seventy-five patients with type 2 diabetes were distributed to inulin group(n=25), Chicory group(n=25), and control group(n=25) with matching their gender and body mass index. The three groups were all given diabetes diets, in addition, the inulin group and Chicory group were added to 15g inulin and 120g Chicory, respectively. All the patients’ fasting blood glucose(FBG), glycated hemoglobin(HbA1c), homeostasis model of assessment for insulin resistence index(HOMA-IR), lipid profiles, aminotransferase, and creatinine were observed at baseline, 4 weeks and 8 weeks, and the change _________________________ 中国医学科学院北京协和医院 营养科（马方，刘鹏举）；内分泌实验室（李明）；检验科（卢洁） 通信作者：马方，北京协和医院营养科，主任医师，电话：652955551，Email：mafang219@126.com of all parameters were compared. Results the number of patients finished this study of three groups were 23(inulin group), 22(Chicory group), and 23(control group), respectively. Compared to control group, the levels of FBG、HbA1c、HOMA-IR、TC(total cholesterol) and LDL had a decrease trend in inulin group at 4 weeks, and had significant decrease at 8 weeks(P0.05), meanwhile, other parameters showed no significant change(P0.05). All the parameters showed no signi