基于可能性构造空间理论的中医药创新配方分析-analysis of innovative recipe of traditional chinese medicine based on possibility structure space theory.docx

based on the achievements of previous studies; methods and process of Chinese medicine compound formulation are studied. This thesis aims on the use of computer to simulate the creative process of innovation formulation of TCM. According to the inspiration from fuzzy thinking, the approach using the Fuzzy quantization method of TCM and fuzzy mathematics method to realize the innovative research of TCM is determined.First, the model of innovation formulation system of TCM is proposed as the theoretical basis of PCST in creative thinking. After the analysis of the features of creative thinking in the process of developing and finding novel drugs, a software basement that combines multi-disciplines and provides data analysis for TCM research is established, and the inspired device of creative thinking to help and inspire researchers of TCM to discover novel drugs and to improve existing compounds is established.In order to realize the digitization of Traditional Chinese medicine information, the method of fuzzy quantification to quantify the knowledge of Chinese medicine is proposed. This method adopts qualitative and quantitative combination mode and integrates various representation methods of existing knowledge to formalize our grasped knowledge of TCM and the formulation process.In the process of innovation formulation, fuzzy clustering analysis is used to optimize similarity selection of single drugs based on quantification, which can reduce the elements in single drugs space. And fuzzy quantization statistics is used to execute similarity selection from obtained innovative compounds. So Coarse filter of innovative compounds can be realized by removing the innovative compounds inconsistent with the original compound from innovative compound space. Then weighted lose-degree in fuzzy pattern recognition is used to execute secondary similarity selection from obtained innovative compounds. Therefore, innovative compounds can be sorted in accordance with close-degree o