HPV感染与宫颈癌前病变相关性研究.docVIP

HPV感染与宫颈癌前病变相关性研究 　　[摘要] 目的：探讨HPV感染与宫颈癌前病变两者之间的相关性。方法：选取2007年2月～2009年1月来我院就诊的180例宫颈病变患者为研究对象，采用杂交捕获2代(HCⅡ)方法定量对宫颈HPV DNA的含量进行检测，用RLU/CO表示病毒负荷，根据HPV DNA含量大小将患者分成5组。结果：在正常组、CIN组和宫颈鳞癌组3组中，高危型HPV DNA的检出率分别为29.35%、62.54%和93.02%，且3个组之间比较，差异有高度统计学意义（P＜0.001）。结论：宫颈病变的严重程度和HPV DNA检出率呈正相关，HPV DNA检出率越高，宫颈病变的程度可能越严重。 　　[关键词] 人乳头瘤病毒；宫颈癌；癌前病变 　　[中图分类号] R737.33[文献标识码] B [文章编号] 1673-7210（2010）11（a）-069-02 　　 　　Correlative research of HPV infection and precancerous lesions of uterine cervix 　　LU Hong1, CHEN Hongguang2 　　(1.Department of Gynaecology and Obstetrics, Jilin Province Liaoyuan City Mining Group General Hospital, Liaoyuan 136201, China; 2.Department of Surgery, Jilin Province Liaoyuan City Dongliao Peoples Hospital, Dongliao 136200, China） 　　[Abstract] Objective: To investigate the relativity between HPV infection and precancerous lesions of uterine cervix. Methods: 180 cases of cervical lesions in our hospital was studied from February 2007 to January 2009, content of cervical HPV DNA were detected by hybrid capture two generations(HCⅡ) of quantitative methods, viral load with RLU/CO was represented. Patients were divided into 5 groups according to the content of HPV DNA. Results: In the normal group, CIN group and squamous cell carcinoma of cervix group, detection rates of high-risk types of HPV DNA were 29.35%, 62.54% and 93.02%, and the comparison had marked statistical significance among the three groups (P＜0.001). Conclusion: The severity of cervical lesions is positively related with detection rate of HPV DNA, detection rate of HPV DNA is the higher, degree of cervical lesions may be more serious. 　　[Key words] Human papilloma virus(HPV); Cervical cancer; Precancerous lesions of uterine cervix 　　 　　人乳头状瘤病毒(human papilloma virus，HPV)感染在宫颈癌发生及发展过程中起重要作用，与子宫颈癌的发生有极为显著的关连，99%以上的子宫颈癌标本中可以发现HPV存在的证据，目前已发现二百多型，其中约四???型可以感染人类生殖道，大多数的感染并无症状，短期间(几个月至2年内)会藉由身体的免疫作用，自行消失。只有少数感染者因为体质(对HPV的免疫反应较差)与病毒(该型HPV感染后较不易为身体清除)的因素，形成慢性感染，才有机会逐渐发展成为癌前病变及子宫颈癌。此等感染后会导致子宫颈癌前病变乃至子宫颈