川芎嗪治疗糖尿病周围神经病变机制临床研究.docVIP

川芎嗪治疗糖尿病周围神经病变机制临床研究 　　摘 要：目的:观察川芎嗪注射液治疗2型糖尿病（T2DM）合并周围神经病变（DPN）的临床疗效及可能机制。方法:2003年6月－2006年6月期间T2DM合并DPN病人112例，在相同的降糖治疗的基础上，随机分为治疗组56例，以川芎嗪注射液治疗；对照组56例，以维脑路通注射液治疗；疗程均为2周，观察两组空腹血糖（FPG）、餐后2h血糖（PPG2h）、糖化血红蛋白（HbA1C）、超敏C反应蛋白（hsC-RP）、尿微量白蛋白(UMA)、内皮素（ET）、血栓素B2（TXB2）、6 - 酮-前列环素F1α（6-Keto-PGF1α）治疗前后的变化。结果：川芎嗪注射液治疗组显效率、总有效率分别为69.64%、96.43%，与对照组（41.07%、67.86%）比较有非常显著性差异（P1c略下降（P0.05），但无统计学意义；6-Keto-PGF1α明显升高（P2明显下降（P 　　关键词：2型糖尿病；糖尿病周围神经病变；川芎嗪注射液；维脑路通注射液? 　　中图分类号：R587.1文献标识码：B 　　文章编号：1673-7717(2008)11-2340-03?? 　　Therapeutic Effect of Ligustrazine Injection? on Diabetic Peripheral Neuropathy 　　?? 　　SUN Ya?dong,MA Yan,LIU Li?ze,QING Jiang,LIU Hui,LIU Bing? 　　(Department of Endocrinology,The People’s Hospital of JilinProvince,Changchun 130021,Jilin，China)?? 　　Abstract:Objective：To observe the clinical effect of ligustrazine injection to treat diabetic peripheral neuropathy（DPN）, and to explore its mechanism of action.Methods：This study was carried out on 112 patients with DPN during Jun.2003 to Jun. 2006. On the base of the same treatment for Type 2 diabetic mellitus，the patients were randomly divided into two groups which included the experimental group and the control group. The experimenta group had 56 patients who were treated with ligustrazine injection while the control group which had 56 patients was treated with venoruton injection. We osberved the changes before and after the treatment in the two groups during the treatment period of two weeks.The FBG，PPG2h,HbA1c,hsC-RP,UMA,6-Keto-PGF1α，ET and TXB2in both groups were observed.Results：The effects of ligustrazineinjection was significantly better than venoruton injection(P1cwere slightly decreased（P0.05）；6-Keto-PGF1α was obviously increased（P2were significantly decreased（P1c（8.18±1.21）%。在相同的糖尿病基础治疗情况下，两组病例在年龄、性别、职业、T2DM病程、DPN病程、入组前HbA1C水平、血糖水平、并发症、合并症等方面差异均无统计学意义（P0.05）。全部病例没有使用任何可能导致如下肢蚁爬感等感觉异常之药物。? 　　1.2 诊断标准[1]（1）所有病例均符合1997年ADA关于T2DM的诊断标准。（2）有四肢感觉异常或运动神经障碍，如：疼痛、麻木、蚁走感、肢体无力；肱二头肌反射减弱或消失，肌电图检查有正中神经、腓