建立肠癌胃肠积热证量化辨证标准研究.docVIP

建立肠癌胃肠积热证量化辨证标准研究 　　【摘要】目的：建立大肠癌胃肠积热证量化标准。方法：在对311例肠癌患者进行临床流行病学调查的基础上，组织专家组对其进行辨证，根据各相关中医症状在胃肠积热证组和非胃肠积热证组中出现状况的差异对这些症状进行赋分；根据专家辩证的结果，应用ROC（receiver operating characteristic curve）曲线的方法选择最佳诊断阈值从而建立量化辨证标准；以专家组统一辨证作为“金标准”对建立的量化标准进行回顾性检验；结果：我们结合专家意见，分析了所有可能与胃肠积热证相关的中医症状，确定口干、口苦、口臭等34个中医症状为肠癌胃肠积热证的候选相关因素；经列联表分析，口苦、口臭等7项在胃肠积热证和非胃肠积热证中的差异有统计学意义（P 　　【关键词】肠癌；胃肠积热证；量化标准；临床流行病学 　　 　　The study of the standardized measurements of Heat Accumulation of gastrointestinal Pattern of colon cancer 　　ZHOU yiyang1, HOU fenggang1△, CENG yi2, GUAN jian2 　　1. Oncology department, Shanghai Municipal Traditional Chinese Medicine hospital, affiliated with Shanghai University of Traditional Chinese Medicine, shanghai, 2000712. Traditional Chinese Medicine department, Shanghai No.8 People’s hospital, shanghai, 200035 　　【ABSTRACT】AIMS: To investigate the methods to standardize the measurement of heat accumulation of gastrointestinal pattern of colon cancer. METHODS: Based on the clinic epidemiologic investigations of 311 cases of colon cancer patients, a board of specialists made differential diagnosis for these patients. Scores were given to heat accumulation of gastrointestinal pattern and non-d heat accumulation of gastrointestinal pattern of colon cancer, according to the difference of symptoms between these two patterns. Grounded on the specialists’ differential diagnosis, applying ROC curve(Receiver Operating Characteristic Curve) methods to select the best diagnostic thresholds and to establish standardized differential diagnostic criteria, then using the concerted differential diagnosis of the specialists board as “Golden Criteria”to retrospectively test the standardized measurements. RESULTS: Combining with the opinions of the specialists, we analyzed all the possible symptoms concerning the heat accumulation of gastrointestinal pattern, we identified 34 symptoms, including bad breath, were the candidate factors of heat accumulation of gastrointestinal pattern. Using the Continge