急性冠状动脉综合征患者血清白细胞介素-37il-37水平及其临床意义-serum interleukin - 37il - 37 level and its clinical significance in patients with acute coronary syndrome.docxVIP

下载本文档

4
0
约8.86万字
约 46页
2018-08-14 发布于上海
举报
版权申诉

急性冠状动脉综合征患者血清白细胞介素-37il-37水平及其临床意义-serum interleukin - 37il - 37 level and its clinical significance in patients with acute coronary syndrome.docx

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

急性冠状动脉综合征患者血清白细胞介素-37il-37水平及其临床意义-serum interleukin - 37il - 37 level and its clinical significance in patients with acute coronary syndrome

ContentsABSTRACT …………………………………………………………………………………………………….. 1INTRODUCTION………………………………………………………………………………………………..3METERIALS AND METHODS……………………………………………………………………………21RESULTS………………………………………………………………………………………………………….23DISCUSSION……………………………………………………………………………………………………29CONCLUSION………………………………………………………………………………………………….37REFRENCES…………………………………………………………………………………………………….38ACKNOWLEDGMENTS…………………………………………………………………………………….45Serum level of Interleukin-37 in patients with Acute Coronary Syndrome and its clinical significance.Department of Cardiovascular Medicine, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCandidate: Kisan Kumar Kushwaha Supervisor: Professor Li Dazhu. MD,Ph.DABSTRACT:Objective. Inflammation plays a major role at all stages of the atherosclerosis process from the early events whereby leukocytes are recruited at sites of subendothelial LDL cholesterol accumulation to the late events, when plaque rupture occurs, leading to thrombus formation and adverse acute coronary events. Interleukin-37 (IL-37) is a new anti-inflammatory cytokine of the interleukin-1 family and shown a fundamental inhibitor of innate immunity. However, the role of Interleukin-37 (IL-37) in the modulation of the atherosclerosis process remains unknown. Therefore, we investigated the serum level of interleukin (IL)-37 in patients with acute coronary syndrome.Materials and Methods:A total of 125 patients were enrolled in the study. 30 patients with Myocardial Infarction (MI) and 30 patients with Unstable Angina (UA) as Acute Coronary Syndrome (ACS), 30 patients with Stable Angina (SA) and 35 subjects with no history of ischemic heart disease as normal control (NC). The patients were grouped on the basis of electrocardiographic (ECG) changes, serum cardiac enzymes elevation and angiographically documented coronary artery stenosis. MI patients had ST changes, T wave inversion or both and serum cardiac enzyme (troponin 0.01nm/ml) elev