3.受体及其细胞信号转导(黄巧冰).ppt.pptVIP

SH- Src homology， 癌基因src保守的同源结构。 RTK的激活 Novel isoform of PTPN18. 蛋白酪氨酸的水解 （酶受体的失活）！ 4. 本身具有酶活性的受体 －细胞膜上起受体作用的酶蛋白 －配体依赖性的蛋白激酶 Signal transduction Cascade 如胰岛素 (insulin) 受体 有参考文献 Insulin receptor DNA 氨基酸 蛋白质 mRNA 胰岛素受体胞外段的保守氨基酸序列 5. 核受体 (nuclear receptor) 1）甾类激素受体：皮质激素和性激素受体 2）非甾类激素受体：甲状腺激素、维生素和前列腺素受体 3）孤儿受体：未找到内源性配体的受体 入核的物质直接影响DNA的转录和翻译！ 核受体 （nuclear receptor）基本结构 “锌指”结构 = HBD (hormone binding domain) DNA结合区域 激素（配体）结合区域 甾类激素受体结构和激活： 9个半胱氨酸残基， 两个“锌指”，P和D盒 HRE：激素反应元件 HSP：热休克蛋白 P D 非甾类激素受体： 甲状腺素、受体及其作用 T3,T4: 甲状腺素 TR: 甲状腺素受体 核受体的生物信息学 介绍来自Nature的一篇综述. 强调医学与生物信息的互相交流和学习 6. 感受病原体信号的受体 Toll like receptors (TLRs) A family of proteins , discovered in 1997, which are structurally related to drosophila Toll and IL-1 receptor Include TLR1—TLR 11 Recognize specific pattern of microbial components, especially from pathogen Regulate the activation of both innate and adaptive immunity TLRs ligands Takeda K, et al 2003 K channels. (A) Topology of the K-channel core TM domain, made up of two TM helices (M1 and M2) plus a re-entrant pore loop containing a short pore helix (P) plus an extended loop that contains the ?lter (F) motif. (B) Fold of the tetrameric core TM domain, looking down the pore axis from the extracellular mouth of the pore. (C) Alignment of the P–F–M2 region of six K channels (two bacterial, KcsA and MthK; two Drosophila Kv channels, Shak and Shaw, and two inward recti?er channels, Kir1.1 and Kir6.2) plus the bacterial glutamate receptor (GluR0). The glycine residue (G99 in KcsA) implicated in K-channel gating is indicated by the red arrow. The domain architecture and corresponding exon structures of PTPN18 and PTPN18B are illustrated. PTPN18B is a novel isoform identi?ed through alternatively splicing analysis. The PTPase domain, coding regions and the untranslated regions are represented in orange, light green and grey respectively. 第三章 受体与细胞间信号转导 Receptor and Intercellular Signal Transduction 基础医学院病理生理教研室 黄巧冰 本教学幻灯引用了大量网上图片，在此对作者表示衷心的感谢。 细胞信号转