The Effect of Caffeine on Neurological Dopamine Production:咖啡因对多巴胺的影响神经.pptVIP

The Effect of Caffeine on Neurological Dopamine Production:咖啡因对多巴胺的影响神经.ppt

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The Effect of Caffeine on Neurological Dopamine Production:咖啡因对多巴胺的影响神经

The Effect of Caffeine on Neurological Dopamine Production Process Dynamics Control October 13th, 2004 Student Name 1 Student Name 2 Presentation Outline Introduction Simulation Assumptions Process Outcomes Laplace via Maple Matlab Simulink Conclusion What is Caffeine? The most commonly used neurological drug worldwide trimethylxanthine, (C8H10N4O2) bitter tasting white powder Common Substances Coffee, tea, soft drinks, and pain medication Caffeine Content: Brewed coffee: 40-180 mg Black Tea: 20-100 mg Excedrin: 65 mg Mountain Dew: 55 mg Green Tea: 8-36 mg What is Dopamine? Neurotransmitter Movement Thought processes Emotions Pleasure “Rewards” centers of the brain The Relationship Between Caffeine and Dopamine Caffeine has ? life of ~6 hours in a healthy person Enters Digestive tract Some caffeine is lost in liver Remainder enters bloodstream Caffeine enters the brain Stimulates excessive dopamine release Blocks uptake receptors Ultimate Response: Simulation Assumptions Body consists of 3 tanks Stomach, Liver, and Brain Flow rates, tank volumes and density remain constant Dopamine production is a first order chemical reaction Caffeine→Dopamine Initial Conditions Simulation Process Focus Amount of Dopamine produced as a function of input Caffeine Mass Balances: Stomach Mass Balance: Liver Mass Balance: Brain Laplace Transform: Steady State Caffeine Impulse Function Caffeine Unit Step Function Caffeine at Steady-State Dopamine at Steady State Dopamine Unit Step Function Dopamine Impulse Function Simulink Unit Step Function For Caffeine Simulink Unit Step Function For Dopamine Simulink Impulse Function for Caffeine Simulink Impulse Function for Dopamine Conclusion Achieved anticipated results in the theoretical process Possible differences in real process Suggestions Thanks to Dr. Rodgers Questions? * * Retrieved from: /.../ caffeine-molecule.gif Retrieved from: http://www.bip.bham.ac.uk/osmart/msctox/ 0.05 dL/s F5 0.0001 dL/s F4 0.0001 dL/s F3 20 dL/

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