和癌症（Regulationof microRNA processing and its implications for development and cancer）.pptVIP

Regulation of microRNA processing and its implications for development and cancerJ. Michael ThomsonThe Hammond Lab Evolutionary Conserved miRNA Cluster The mir17-92 cluster resides in a region with known amplifications in cases of DLBCL, follicular and mantle cell lymphoma, and several lung and head/neck carcinomas Lymphoma cell lines with known amplification for C13orf25 exhibit high level expression for miR17-92 compared to cell lines lacking amplification. All cell lines exhibit reduced expression of let7 family members compared to cord blood B-cells Global Reduction in miRNAs in