【持续性肾脏替代治疗CRRT英文精品课件】Lithium Poisoning when is hemodialysis indicated.pptVIP

Lithium Poisoning: when is hemodialysis indicated? Kent R. Olson, MD Medical Director - SF Division California Poison Control System Case A 32 year old woman ingested 20 lithium carbonate 300 mg tablets in a suicide attempt She is drowsy and her speech is slurred Her serum Li = 6 mEq/L Hemodialysis needed? Lithium Alkali metal (like Na, K) Widely used for bipolar disorder Therapeutic range 0.6-1.2 mEq/L Toxicity = mainly CNS Tremor, slurred speech, muscle twitching Confusion, delirium, seizures, coma Recovery may take weeks Toxicity may occur as a result of acute overdose or chronic use Pharm