毕业论文外文翻译-壳聚糖-多酚纳米颗粒的合成和性质及细胞毒性的研究.docVIP

文献翻译：原文 Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles a b s t r a c t：Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407?0 nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 8?6% and 44?3%, respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant antitumor activities. Introduction Nowadays, cancer is the major public health problem and the existing treatment approaches and surgical techniques have not been able to cope effectively with this dreaded disease. Because of this, chemoprevention is a valid approach to reduce the incidence of cancer [1]. As an effective cancer chemopreventive agent, tea polyphenols are known to be strong antioxidants and anticarcinogenic activities [2]. In vitro and animal studies provide strong evidence that polyphenols derived from tea may possess the bioactivity to inhibit tumorigenesis in a variety of animal models of carcinogenesis [3]. Tea polyphenols has been shown to inhibit the development of cancer in animal models of oral, esophageal, forestomach, stomach, intestinal, colon, skin, liver, bladder, prostate, and breast cancer [4,5]. Although tea polyphenols are widely used for the prevention and treatment of cancer, its therapeutic effects are always limited by severe adverse effects, such as the stability of biological activity in tissue and bioavailability in vivo, etc. [6]. There have been reported that