发生的以呼吸频数及窘迫和严重的进行性低氧血症为特征的急性呼吸衰竭课件.pptVIP

Different serum adiponectin levels based on different AHI in OSAS patients * * Effect of CPAP treatment on hypoadiponectinemia in male patients with obstructive sleep apnea syndrome Zhang Xilong, Yin Kaisheng  Tha First Affiliated Hospital of Nanjing  Medical University, Nanjing, China Research Background Adiponectin, secreted by adipocytes, has been found recently to be associated with diabetes, obesity and some cardiovascular diseases.  Recent research suggested that obstructive sleep apnea syndrome (OSAS) might be independently associated with hypoadiponectinemia, which was linked to some complications of OSAS, such as hypertension, diabetes, etc. ObjectiveTo investigate the effect of continuous positive airway pressure (CPAP) treatment on serum diponectine levels in male OSAS patients.  METHODS Diagnosis of OSASA Compumedic polysomnographer was used to measure and record overnight polysomnography (PSG) parameters.The mininal criteria for diagnosis of SAS is apnea hypopnea index (AHI)≥5.  The event was considered obstructive when chest and abdominal respiratory movements existed during apnea.  Subjects 23 adult male patients with moderate or severe OSAS Age : 41.4±11.8 yrs (38 ~ 64 yrs )BMI : 24.7±2.1 2 The exclusion criteria: type 2 diabetes or FBG 7.0mg/L  BMI 28  cardiovascular diseases  other chronic respiratory diseases  Test of serum adiponectin Three ml of venous blood was drawn at 7:00am following 12 hours’ overnight fasting. Serum adiponectin level was measured by radioimmunoassay. The agent kit for adiponectin testing was providedby LINCO Research Inc, USA. Their blood samples were collected and mean arterial pressure (MAP, diastolic Bp + 1/3 pulse pressure)was measured at 6:00 A.M.before CPAP treatment on day 3,  day 7,  day 14 of CPAP treatment RESULT Comparison of serum adiponectin levels, AHI and  MAP before an