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Predictive Models of CancerXenograft Models Of Childhood Solid Tumors Solid Malignancies Group St. Jude Children’s Research Hospital Human Tumor Xenografts Human cancers grown in immune-incompetent mice/rats. Models of most childhood solid tumors. Models of childhood ALL established. Xenograft Model Validation(Rhabdomyosarcoma) Model tumors respond qualitatively and quantitatively to drugs known to be active in the respective clinical disease: Diagnosis models: highly sensitive. Relapse models: significantly less responsive Models prospectively identify effective agents. Retrospective and P