150例结直肠癌浸润深度与淋巴结转移情况临床病理研究.docVIP

150例结直肠癌浸润深度与淋巴结转移情况临床病理研究 　　[摘要] 目的 探讨结直肠癌浸润深度与淋巴结转移的关系以及CD44v6、p53、nm23-H1和COX-2表达情况，为临床治疗和预后评估提供参考。 方法 回顾性分析150例结直肠癌患者的病理资料，统计结直肠癌浸润深度、临床分期与淋巴结转移之间的关系；采用免疫组化方法检测CD44v6、p53、nm23-H1和COX-2在结直肠癌患者癌及癌旁组织中的表达。 结果 淋巴结转移率随着结直肠癌浸润深度的加深而增加（P0.05）；不同组织类型及不同Dukes分期CD44v6、COX-2、nm23-H1表达差异有统计学意义（P 　　[关键词] 结直肠癌；浸润深度；淋巴转移；免疫组化；临床病理 　　[中图分类号] R574.63 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0004-04 　　A clinicopathological study of 150 cases of colorectal cancer depth of invasion and lymph node metastasis 　　HUANG Xiao-xing1 HUANG Shi-yong1 XIE Wei2 　　1.Department of Pathology，People′s Hospital of Yangjiang City in Guangdong Province，Yangjiang 529500，China；2.Department of Second Surgery，People′s Hospital of Yangjiang City in Guangdong Province，Yangjiang 529500，China 　　[Abstract] Objective To investigate the depth of invasion of colorectal cancer with lymph node metastasis and the expression of CD44v6，p53，nm23-H1 and COX-2，in order to provide clinical basis for treatment and prognosis. Methods The pathological datas of 150 cases with colorectal cancer was retrospectively analyzed，statistics was performed on the depth of invasion，clinicalthe relationship between the period and lymph node metastasis；the colorectal expression of CD44v6，p53，nm23-H1 and COX-2 in cancer and adjacent tissues of patients with rectal cancer were detected by immunohistochemistry. Results Lymph node metastasis rate increased along with the deepening of the depth of invasion of colorectal cancer（P0.05）；the differences of CD44v6， COX-2，p53 and nm23-H1 expression in different histological types and Dukes stages were all statistically significant（P 　　[Key words] Colorectal cancer；Depth of invasion；Lymph node metastasis；Immunohistochemistry；Clinical pathology 　　结肠癌浸润深度、淋巴结转移是导致癌症患者死亡的主要原因，在结肠癌治疗过程中正确认识、判断与处理淋巴结转移非常重要。许多学者试图找到与结直肠癌分期和预后的相关指标，以指导治疗，目前与肿瘤的浸润与转移相关的标志物成为研究热点，因此本文通过研究结直肠癌浸润深度、分化程度与淋巴结转移相关关系，探讨CD44v6、p53、nm23-H1及COX-2在结直肠癌组织中的表达情况，为临床确定结肠癌根治术淋巴结区清扫范围及选择合理治疗方案提供科学依据，现报告如下。 　　1 资料与方法 　　1.1 一般资料