Addenbrooke改良认知评估量表在帕金森病患者认知障碍的价7.docVIP

Addenbrooke改良认知评估量表在帕金森病患者认知障碍的价值初探 蔡荇 韦存胜 顾小花 程欣欣 张楚楚 王江波 孙琦 许利刚 徐俊 摘要：目的 应用Addenbrooke改良认知评估量表(ACE-R)探讨帕金森病(PD)患者认知功能障碍情况。方法 对某三甲专科医院神经科门诊及住院治疗的24例PD患者行ACE-R评估。 结果 24例PD中11例MMSE异常与13例MMSE正常的患者比较，两组间在年龄方面差异有显著性(P0.05)，而病程、Hoehn-Yahr分期及UPDRS-motor差异无显著性；24例PD中14例ACE-R异常与10例ACE-R正常的患者比较，两组间年龄差异无显著性，而病程、Hoehn-Yahr分期及UPDRS-motor差异均有显著性(P0.05)。两组在ACE-R各分项中(注意和定向、记忆、语言流利性、语言及视空间)差异显著性明显(P0.005)。结论 ACE-R用作评估PD合并认知障碍敏感性高于MMSE，较MMSE更适合用于PD患者的认知障碍筛查。 关键词：帕金森病、认知障碍、痴呆、Addenbrooke改良认知评估量表 Preliminary study on application of the Addenbrookes Cognitive Examination-revised to assessment of cognition in Parkinson’s disease CAI Xing, WEI Cun-sheng, GU Xiao-hua, CHENG Xin-xin, ZHANG Chu-chu, WANG Jiang-bo, SUN Qi, XU Li-gang, XU Jun Department of Neurology, JIangsu Province Official Hospital, Nanjing 210024, China Abstract：Objective To investigate the application of the Addenbrookes Cognitive Examination-revised(ACE-R) to the assessment of global cognition in Parkinson’s disease(PD). Methods Twenty-four PD patients were included. Their cognitive functions were assessed according to the ACE-R scales. Results Compared with 11 cases of abnormal MMSE scores and 13 cases of normal MMSE scores in 24 cases of PD patients, the age was significantly different in 2 groups with MMSE(P0.05),but the duration of symptoms, Hoehn-Yahr stage and UPDRS-motor were not significantly different. Compared with 14 cases of abnormal ACE-R scores and 10 cases of normal ACE-R scores in 24 cases of PD patients, the duration of symptoms, Hoehn-Yahr stage and UPDRS-motor were significantly different in 2 groups with ACE-R (P0.05),but the age was not significantly different. The scores of five cognitive subdomains in ACE-R(Attention and concentration, Memory, Verbal fluency, Language and Visuospatial) in 2 groups with ACE-R were significantly different(P＜0.005). Conclusion The ACE-R has higher sensitivity than the MMSE for cognitive assessment in PD patients. The ACE-R is more suitable than the MMSE as a cog