Random Field Theory Wellcome Trust Centre for euroimaging影像学威康信托中心的随机场理论.pptVIP

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Random Field Theory Wellcome Trust Centre for euroimaging影像学威康信托中心的随机场理论.ppt

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Random Field Theory Wellcome Trust Centre for euroimaging影像学威康信托中心的随机场理论

18/11/2009 RFT for dummies - Part II * Thank you ? 18/10/2009 * * * * We want to know if and where a significant activation or change in response to our experimental paradigm has occurred. Thus, we need to come up with some hypothesis and test it. As we are actually going through this process for every single voxel on our image, this brings us into the trouble of multiple comparison. * * * We can make statistical inference via the rejection of a null hypothesis. Our null hypothesis is the following: We reject it if we are pretty certain that it is false, usually we decided to reject it if the probability that our sample just comes from a null distribution is less than 5%. * * Explain z-score * * If you perform n tests, each of them significant at a level of alpha, then the probability that at least one of them comes out significant is ≤ n times alpha * * * * Smoothing: Each voxel`s new value is set to an average of itself and that voxels it`s neighborhood The original pixels value receives the heaviest weight and neighbouring pixels receive smaller weights as their distance to the original pixel increases. Kernel defines the shape of the function that is used to take the average of the neighbouring points. FWHM: measure to describe the width of the kernel, also used as a measure for the smoothness of a picture RFT for dummies - Part I Random Field Theory Methods for Dummies 2009 Lea Firmin and Anna Jafarpour 18/11/2009 RFT for dummies - Part I * Normalisation Statistical Parametric Map Image time-series Parameter estimates General Linear Model Realignment Smoothing Design matrix Anatomicalreference Spatial filter StatisticalInference RFT p 0.05 18/11/2009 RFT for dummies - Part I * Overview What‘s this all about? Hypothesis testing Multiple comparison First approach: Bonferroni correction Problem: non-independent samples… Improved approach: random field theory Implementation in SPM8 18/11/2009 RFT for dummies - Part I * Single Voxel Level A voxel (volume