肝细胞癌分子靶向治疗研究进展课件.ppt

分子靶向药物—激光制导炸弹 主要是针对肿瘤发生、发展过程中的关键大分子，即参与肿瘤发生、发展过程中的细胞信号传导和其他生物学途径的重要靶点,或是通过强力阻止肿瘤血管生成，从而抑制肿瘤细胞的生长、增殖和转移播散，发挥特异性抗肿瘤作用。 * Selection of patients with well preserved liver function (Child–Pugh A) was important to assess the efficacy of the drug inclusion of patients with more advanced liver dysfunction (Child–Pugh B or C) may have masked sorafenib activity due to liver disease-associated deaths. Treatment continued until radiological progression (RECIST) and symptomatic progression, or unacceptable toxicity, or death. Primary endpoints OS measured from date of randomization until date of death from any cause TTSP measured by patient-reported symptoms questionnaire symptomatic progression was defined as ≥4-point decrease from baseline score, confirmed 3 weeks later as a decrease of 4 points by FHSI8, death, or deterioration to ECOG PS 4 (whichever occurred first). Secondary endpoints TTP was defined as time from randomization to disease progression (RECIST), based on independent radiological review DCR was defined as the percentage of patients who had a best response rating (RECIST) of complete response, partial response or stable disease, maintained for ≥28 days, based on independent radiological review safety was assessed in all patients receiving at least one dose of study drug using CTCAE v3.0. Llovet JM, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008 [TBC] * Bisphosphonates Overview * Brivanib是一种口服血管内皮生长因子受体和纤维细胞生长因子受体通路双重抑制剂，由百时美施贵宝公司开发. Bisphosphonates Overview * * * Bisphosphonates Overview * Bisphosphonates Overview * Bisphosphonates Overview * * * * * * * * * * Manley et al. Expert Opin Investig Drugs. 2002;11:1715. *** THIS SLIDE IS ANIMATED *** Several novel therapeutic approaches have directly targeted VEGF and its receptor. VEGF represents a family of peptide growth factors that bind to at least 3 different isoforms of receptor tyrosine kinases, VEGF-1, VEGF-2, VEGF-3. VEGF is primarily regulated by growth factors (such a