鲑鱼降钙素对老年骨质疏松性椎体骨折患者骨代谢、骨折愈合及腰背痛的干预效果.docxVIP

鲑鱼降钙素对老年骨质疏松性椎体骨折患者骨代谢、骨折愈合及腰背痛的干预效果156 中国临床康复第9巷第27j努2005-07.21出版 ChineseJournalofClinicalRehabilitation,July212005VoL9No.27 鲑鱼降钙素对老年骨质疏松性椎体骨折患者骨代谢,骨折愈合及 腰背痛的干预效果☆ 钟俊,周月秉,刘世清 ? 临床研究? 武汉大学人民医院骨科,湖北省武汉市430o60 通讯作者:钟俊☆.女,1965年生,湖北省枣阳市人,汉族,武汉大学在 读博士,副主任医师,副教授,主要从事创伤骨科,关节镜及骨质疏松的 治疗Zhon~un8496@ 中圈分类号:R681.4文献标识码:A文章编号:1671-5926(2005)27-0156-02 牧稿日期:2005-0l一27修回日期:2005—o6—20【05/NH/YLl Intel~elltionaleffeetsofl~tllllOllealcitoninoRthebone metabolism.fracturehealingandlowbackpaininelderly patientswithosteoporotlcvertebralfractureZhongJunZhou Yue.rong.UuShi—qingDepartmentofOrthopaedics,RenminHospitalof WuhanUnivemityWuhan430O60.HubeiProvince,China Correspondenceto:ZhongJun,A-,Studyingfordoctorate,Associatechief physieian,Associateprofessor,DepartmentofOrthopaedics,RenminHos— pitalofWuhanUnivemity.Wuhan430O60.HubeiProvince,China Zhongiun8496@valloo,com Received:2005—0l一27Accepted:2005—l卜20 Abstract A】Toobservethetherapeuticeriectsofsalmoncalcitonin.whichcaII directivelyinhibitboneabsorption,adjusttheactivityandnumberofos. teoblasts.andaccelerateosteogenesis,onthebonemetabolism,fracture healingandlowbackpaininelderlypatientswithosteoporoticvertebral fracture. METItODS:(1)At0talof138elderlypatientswithosteoporoticvertebral fracture,whowereselectedfromtheDepartmentofOrthopaedics,Renmln Hospital0fWuhanUnivemitybetweenJune20oOandJune2003.were randomlydividedinto— twogroups:controlgroup=65)andsalmoncalci- toningroup(n=73).②AUthepatientslayonthebedwithasoftpillowat lowerbackorupperback.andassistedbyoralmid.patentmedicine,be. sides.thoseinthesalmoncalcitoningroupweretreatedbyintramuscular injectionofMiacalcic.onceadayforamonthcontinuously,theyalsotook calcium6OOmgperday.(Beforetreatmentand1monthaftertreatment, bloodosteocaltinwasdeterminedwithradioimmunoassay,thesecondurine alterget.upinthemorningwascollected.urinarycalciumwasdetected witlItheazothreearsinemethed.urinaryhydroxyprolinewithchemilumi— noimmunoassay,urinarycreatininewiththebasicbitteracidmethod,and theurinarycalcium/urin