From Biomarkers to Diagnostic Tools Used in the Clinic从生物标志物应用于临床诊断工具.pptVIP

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2018-06-23 发布于四川
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From Biomarkers to Diagnostic Tools Used in the Clinic从生物标志物应用于临床诊断工具.ppt

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From Biomarkers to Diagnostic Tools Used in the Clinic从生物标志物应用于临床诊断工具

Introduction of new tests on tumor tissue in pathology Many new tests are expected in the near future Pathology laboratories are increasingly involved Which laboratory should do the test?: Any laboratory interested at developing new tests? Manufacturers which developed the test? Ministry of health? Conclusions and future direction There is a need to anticipate new diagnostic tests on tumor tissue Scientific watch to identify potential new tests (“advance notice”) Experts should be asked to recommend reference labs Coordination with DLCC and MSSS Biomarkers on tumor tissue: from research to diagnostic tools used in the Clinic Bernard Têtu MD Professor of Pathology Laval University Conflict of interest Currently no conflict of interest to declare. I have been consultant for Diagnocure until 2009 Biomarker Gutman et al. Nature reviews/cancer 2006; 6:565-571 Definition: ??Any measurable diagnostic indicator that is used to assess the risk or presence of disease.?? FDA (diagnostic): determining future risk of disease screening for disease confirming presence of disease determining prognosis or staging monitoring and/or optimizing treatment outcomes drug response toxic reaction to drugs Personalized medicine Biomarkers are expected to play an increasingly important role Cares must be efficient, safe, cost effective integration of pharmaceutical and diagnostic activities are expected to increase We expect more tests to be performed by IHC in pathology laboratories because of ease and low cost Medical product development Canada: Health Canada Québec: Conseil du médicament Tests in pathology Ontario: QMP-LS / CCO Québec: ? Introduction of new tests on tumor tissue in pathology Many new tests are expected in the near future Pathology laboratories are increasingly involved Which laboratory should do the test?: Any laboratory interested at developing new tests? Manufacturers which developed the test? Ministry of health? History of immunohistochemistry Early 1980?’s: f