美托洛尔对扩张型心肌病qt间期离散度及室性心律失常变化的研究 - 论文.docVIP

美托洛尔对扩张型心肌病qt间期离散度及室性心律失常变化的研究 - 论文 关键字：基础 患者 治疗 研究 明显 扩张型心肌病 心肌 心电图 美托洛尔 室性心律失常 【关键词】 ,扩张型心肌病 摘 要：目的：探讨美托洛尔治疗对扩张型心肌病(D)患者心电图QT间期离散度(QTd)及室性心律失常的影响。方法：80例D患者分为基础治疗组（A组，40例）及基础治疗加美托洛尔治疗组（B组，40例），给予B组在基础治疗上加服美托洛尔25g/tid,疗程9个月。治疗前后应用24h动态心电图和多普勒超声心动图，观测QTd、QTd、HR、室性心律失常(VA)如室性早搏(PV)、非持续性室性心动过速(NSVT)）的发生情况、左心室射血分数(LVEF)。结果：B组QTd、QTd及室性心律失常（VA）发生率均较A组显著降低(P均0.01),左室射血分数(LVEF)较A组明显提高(P0.01)，而HR、血压无明显变化(P0.05)。提示B组疗效明显优于A组。结论：D患者长期应用美托洛尔可显著降低QTd、QTd及VA的发生率,改善心功能,改善预后。　　关键词： 美托洛尔； 扩张型心肌病； QT离散度； 室性心律失常　　Study f etprll in Effeting the QTd and Ventriular Arrhythias in Dilated ardiypathy　　Abstrat： bjetive： The ai f the study as t evaluate hether the additin f etprll t nventinal therapy in dilated ardiypathy(D) patients is assiated ith further benefits in shrtening QT intervals dispersins((QTd) and reduing ventriular arrhythias(VA). ethds： 80 D patients ere randly allated t t grups (A and B grup). A grup (nventinal therapy grup), 40 ases ,ith nly used drugs f ardiglyside ,diuresis and angitens innverting enzye inhibitr ediine. B grup (nventinal therapy and etprll grup), 40 ases, patients ere treated ith nventinal therapy and etprll 25g/tid. The urse f treatent as 9 nths. Befre and after the treatent,24 hur Hlter as used t nitr HR,VA suh as PV and NSVT, and Dppler ultrasund ardigra as used t easure left ventriular ejetin fratin(LVEF).Results： After 9 nths treatent, LVEF as signifiantly iprved , QTd、QTd ere signifiantly shrtened and VA as arkedly redued in the etprll grup pared ith that in the nventinal therapy grup(P0.05),but there as n signifiantly differene beteen the t grups in the HR and the pressure (P0.05). nlusins： etprll upled ith nly used ardiaglyside, diuresis and AEI ediine has a better urative effet in shrtening QTd、QTd , reduing ventriular arrhythias and iprving left ventriular funtin in dilated ardiypathy.　　Key rds： etprll； Dilated ardiypathy; QT intervals dispersins; Ventriular arrhythias　　室性心律失常是扩张型心肌病(D)的严重并发症之一,常可引起猝死。扩张型心肌