Disorders MBBS Students Club肾上腺疾病 MBBS学生俱乐部课件.ppt

SIGNS SYMPTOMS IN FEMALES Virile characteristics in women girls. Hirsutism: hair on the face, chin and upper lips. Deeper voice. Occasionally baldness. Masculine distribution of hair on the body. Deposition of proteins in a masculine manner. IN MALES Precocious development in boys. In prepubertal male, a virilizing adrenal tumour causes same characteristics as in the female plus rapid development of the male sex organs. In adult male, the virilising characteristics are often masked by the virilising effects of Testosterone. Diagnosis is made by the presence of excess 17-ketosteroids in the urine. B is the correct answer. * To understand the symptoms of the HYPER HYPOsecretion of the different zones of the adrenal cortex, it is important to review their overall functions…. * As the name suggests, primary aldosteronism is due to defect in the zona glomerulosa itself. When there are secondary causes like inappropriate high activity of the renin-angiotensin-aldosterone system (produced by the atherosclerosis and narrowing of renal arteries), then the symptoms are the same but the diagnosis will be made because of high aldosterone and high levels of renin as compared to the Primary aldosteronism when the diagnosis is made by the high levels of aldosterone and low levels of renin. * The HTN is usually moderate because of aldosterone escape (210/125 mmHg). * The symptoms will be the same in both the disorders but the cause needs to be ascertained to treat the patient. Of course, if there is a tumour of zona glomerulosa, then one should go for removal of the zone cells only or pharmacological antagonism of the MR. If the cause is hyperactivity of the renin-angiotensin system, then appropriate treatment should be done. * Furthermore, lack of cortisol reduces the mobilization of both proteins and fats from the tissues, thereby depressing many other metabolic functions of the body. This sluggishness of energy mobilization when cortisol is not available is one of the